Neurochemical plasticity in the enteric nervous system of a primate animal model of experimental Parkinsonism.

t. chaumette, t. lebouvier, p. aubert, b. lardeux, c. qin, q. li, d. accary, e. bézard, s. bruley des varannes, p. derkinderen, m. neunlist
Neurogastroenterology & Motility. 2009-02-01; 21(2): 215-222
DOI: 10.1111/j.1365-2982.2008.01226.x

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1. Neurogastroenterol Motil. 2009 Feb;21(2):215-22. doi:
10.1111/j.1365-2982.2008.01226.x. Epub 2008 Dec 5.

Neurochemical plasticity in the enteric nervous system of a primate animal model
of experimental Parkinsonism.

Chaumette T(1), Lebouvier T, Aubert P, Lardeux B, Qin C, Li Q, Accary D, Bézard
E, Bruley des Varannes S, Derkinderen P, Neunlist M.

Author information:
(1)Inserm, U913, Nantes, France.

Emerging evidences suggest that the enteric nervous system (ENS) is affected by
the degenerative process in Parkinson’s disease (PD). In addition lesions in the
ENS could be associated with gastrointestinal (GI) dysfunctions, in particular
constipation, observed in PD. However, the precise alterations of the ENS and
especially the changes in the neurochemical phenotype remain largely unknown both
in PD and experimental Parkinsonism. The aim of our study was thus to
characterize the neurochemical coding of the ENS in the colon of
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys, a
well-characterized model of PD. In the myenteric plexus, there was a significant
increase in the number of neurons per ganglia (identified with Hu), especially
nitric oxide synthase immunoreactives (IR) neurons in MPTP-treated monkeys
compared to controls. A concomitant 72% decrease in the number of tyrosine
hydroxylase-IR neurons was observed in MPTP-treated monkeys compared to controls.
In contrast no change in the cholinergic or vasoactive intestinal peptide-IR
population was observed. In addition, the density of enteric glial cells was not
modified in MPTP-treated monkeys. Our results demonstrate that MPTP induces major
changes in the myenteric plexus and to a lesser extent in the submucosal plexus
of monkeys. They further reinforce the observation that lesions of the ENS occur
in the course of PD that might be related to the GI dysfunction observed in this

DOI: 10.1111/j.1365-2982.2008.01226.x
PMID: 19077145 [Indexed for MEDLINE]

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