Modeling Parkinson’s disease in primates: The MPTP model.

G. Porras, Q. Li, E. Bezard
Cold Spring Harbor Perspectives in Medicine. 2011-12-22; 2(3): a009308-a009308
DOI: 10.1101/cshperspect.a009308

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1. Cold Spring Harb Perspect Med. 2012 Mar;2(3):a009308. doi:

Modeling Parkinson’s disease in primates: The MPTP model.

Porras G(1), Li Q, Bezard E.

Author information:
(1)University de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293
Bordeaux, France; CNRS, Institut des Maladiesw Neurodégénératives, UMR 5293
Bordeaux, France.

The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) primate models of
Parkinson’s disease (PD) reproduce most, although not all, of the clinical and
pathological hallmarks of PD. The present contribution presents the possibilities
offered by the MPTP monkey models of PD to readers with minimal knowledge of PD,
emphasizing the diversity of species, route and regimen of administration,
symptoms and pathological features. Readers would eventually find out that there
is not a single MPTP monkey model of PD but instead MPTP monkey models of PD,
each addressing a specific experimental need.

DOI: 10.1101/cshperspect.a009308
PMCID: PMC3282499
PMID: 22393538 [Indexed for MEDLINE]

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