Metabolic activity of the subthalamic nucleus in a primate model of L-dopa-unresponsive parkinsonism.
Neurological Research. 2010-12-01; 32(10): 1050-1053
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1. Neurol Res. 2010 Dec;32(10):1050-3. doi: 10.1179/016164110X12807570509934. Epub
2010 Aug 31.
Metabolic activity of the subthalamic nucleus in a primate model of
Fernagut PO(1), Barraud Q, Bezard E, Ghorayeb I, Tison F.
(1)Université Victor Segalen-Bordeaux 2, Centre National de la Recherche
Scientifique, Bordeaux Institute of Neuroscience, UMR 5227, Bordeaux, France.
Increased activity of the subthalamic nucleus (STN) is critical in mediating
motor symptoms of Parkinson’s disease. To determine if altered STN activity also
occurs in levodopa (L-Dopa)-unresponsive parkinsonism due to a combined nigral
and striatal degeneration, metabolic activity of the STN was assessed using
cytochrome oxidase (CO) histochemistry in monkeys with nigral, striatal, or
nigral+striatal degeneration induced by
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and/or 3-nitropropionic acid
(3NP). MPTP- and MPTP+3NP-treated monkeys had a similar parkinsonian score and
were clinically indistinguishable. However, CO activity in the STN was
significantly increased in MPTP-induced parkinsonism but not in MPTP+3NP-induced
striatonigral degeneration. These results indicate that metabolic activity of the
STN is normal following a combined nigral+striatal degeneration and may help to
understand the lack of effect of STN stimulation in L-Dopa-unresponsive
PMID: 20810027 [Indexed for MEDLINE]