Mammalian target of rapamycin complex 1 (mTORC1) signaling in energy balance and obesity.
Physiology & Behavior. 2009-07-01; 97(5): 520-524
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1. Physiol Behav. 2009 Jul 14;97(5):520-4. doi: 10.1016/j.physbeh.2009.03.006. Epub
2009 Mar 16.
Mammalian target of rapamycin complex 1 (mTORC1) signaling in energy balance and
(1)INSERM U862, Avenir group Physiopathology of Energy Balance and Obesity,
Université de Bordeaux 2, Bordeaux, France.
Energy balance is guaranteed by a complex circuitry that in the brain, and in the
hypothalamus in particular, integrates and coordinates several types of signals,
including hormones and nutrients, so to match energy expenditure to energy needs.
Similar to individual cells, the hypothalamus also profits from intracellular
pathways known to work as fuel sensors to maintain energy balance. The mammalian
target of rapamycin complex 1 (mTORC1) pathway has been recently implicated in
such function, due to its ability to integrate nutrient and hormonal signals to
control food intake and body weight. This review therefore describes recent
advances made in understanding the role of the hypothalamic mTORC1 pathway in
energy balance regulation and its possible contribution to the metabolic
dysregulation associated with diet-induced obesity.
PMID: 19296907 [Indexed for MEDLINE]