Lysyl oxidase deficiency: a new cause of human arterial dissection
1. Heart. 2005 May;91(5):e33.
Lysyl oxidase deficiency: a new cause of human arterial dissection.
Sibon I(1), Sommer P, Lamaziere JM, Bonnet J.
Author information:
(1)CHU Bordeaux, Bordeaux, France.
Spontaneous coronary artery dissection is a rare cause of myocardial ischaemia.
The underlying mechanism is unknown but some dissections are associated with
extracellular matrix disorganisation of genetic origin. A deficiency in
extracellular matrix protein cross links has rarely been studied. A single
clinical case of spontaneous coronary artery dissection is reported. Lysyl
oxidase (LOX) and extracellular matrix organisation were investigated by skin
immunohistology and polymerase chain reaction of LOX expression. Both approaches
found a dramatic LOX decrease. LOX deficiency has a major role in human arterial
wall organisation during development. The suspected mechanism is an elastin or
collagen polymer cross linking deficiency.
DOI: 10.1136/hrt.2004.053074
PMCID: PMC1768870
PMID: 15831618 [Indexed for MEDLINE]