Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model.

Giuseppe Schiavone, Fabien Wagner, Florian Fallegger, Xiaoyang Kang, Nicolas Vachicouras, Beatrice Barra, Marco Capogrosso, Jocelyne Bloch, Gregoire Courtine, Stephanie P. Lacour
2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). 2018-07-01; :
DOI: 10.1109/embc.2018.8512584

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1. Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:1432-1435. doi:
10.1109/EMBC.2018.8512584.

Long-term functionality of a soft electrode array for epidural spinal cord
stimulation in a minipig model.

Schiavone G, Wagner F, Fallegger F, Kang X, Vachicouras N, Barra B, Capogrosso M,
Bloch J, Courtine G, Lacour SP.

Long-term biointegration of man-made neural interfaces is influenced by the
mechanical properties of the implant materials. Substantial experimental work
currently aims at replacing conventional hard implant materials with soft
alternatives that can favour a lower immune response. Here we assess the
performance of a soft electrode array implanted in the spinal epidural space of a
minipig model for a period of 6 months. The electrode array includes
platinum-silicone electrode contacts and elastic thin-film gold interconnects
embedded in silicone. textbfIn-vivo electrode impedance and voltage transients
were monitored over time. Following implantation, epidural stimulation produced
muscle-specific evoked potentials and visible muscle contractions. Over time,
postoperative and stimulation induced changes in electrode impedance were
observed. Such trends provide a basis for future technological improvements
aiming at ensuring the stability of soft implantable electrodes for neural
interfacing.

DOI: 10.1109/EMBC.2018.8512584
PMID: 30440661 [Indexed for MEDLINE]


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