Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model.
2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). 2018-07-01; :
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1. Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:1432-1435. doi:
Long-term functionality of a soft electrode array for epidural spinal cord
stimulation in a minipig model.
Schiavone G, Wagner F, Fallegger F, Kang X, Vachicouras N, Barra B, Capogrosso M,
Bloch J, Courtine G, Lacour SP.
Long-term biointegration of man-made neural interfaces is influenced by the
mechanical properties of the implant materials. Substantial experimental work
currently aims at replacing conventional hard implant materials with soft
alternatives that can favour a lower immune response. Here we assess the
performance of a soft electrode array implanted in the spinal epidural space of a
minipig model for a period of 6 months. The electrode array includes
platinum-silicone electrode contacts and elastic thin-film gold interconnects
embedded in silicone. textbfIn-vivo electrode impedance and voltage transients
were monitored over time. Following implantation, epidural stimulation produced
muscle-specific evoked potentials and visible muscle contractions. Over time,
postoperative and stimulation induced changes in electrode impedance were
observed. Such trends provide a basis for future technological improvements
aiming at ensuring the stability of soft implantable electrodes for neural
PMID: 30440661 [Indexed for MEDLINE]