Lack of spontaneous age-related brain pathology in Octodon degus: a reappraisal of the model.
Sci Rep. 2017-04-04; 7(1):
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1. Sci Rep. 2017 Apr 4;7:45831. doi: 10.1038/srep45831.
Lack of spontaneous age-related brain pathology in Octodon degus: a reappraisal
of the model.
Bourdenx M(1)(2), Dovero S(1)(2), Thiolat ML(1)(2), Bezard E(1)(2), Dehay
(1)Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000
(2)CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux,
Neurodegenerative diseases are characterized by the degeneration of specific
brain areas associated with accumulation of disease-related protein in extra- or
intra-cellular deposits. Their preclinical investigations are mostly based on
genetically-engineered animals. Despite their interest, these models are often
based on high level of disease-related protein expression, thus questioning their
relevance to human pathology and calling for the alternate use of ecological
models. In the past few years, Octodon degus has emerged as a promising animal
model displaying age-dependent Alzheimer’s disease-related pathology. As
neurodegenerative-related proteins often co-deposit in the brain of patients, we
assessed the occurrence of α-synuclein-related pathology in this model using
state-of-the-art immunohistochemistry and biochemistry. Despite our efforts and
in contrast with previously published results, our study argues against the use
of Octodon degus as a suitable natural model of neurodegenerative disorder as we
failed to identify either Parkinson’s disease- or Alzheimer’s disease-related