Kainate receptors in the hippocampus.
Eur J Neurosci. 2014-04-17; 39(11): 1835-1844
DOI: 10.1111/ejn.12590
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1. Eur J Neurosci. 2014 Jun;39(11):1835-44. doi: 10.1111/ejn.12590. Epub 2014 Apr
17.
Kainate receptors in the hippocampus.
Carta M(1), Fièvre S, Gorlewicz A, Mulle C.
Author information:
(1)Interdisciplinary Institute for Neuroscience, CNRS UMR 5297, University of
Bordeaux, F-33000, Bordeaux, France.
Kainate receptors (KARs) consist of a family of ionotropic glutamate receptors
composed of the combinations of five subunits, GluK1-GluK5. Although KARs display
close structural homology with AMPA receptors, they serve quite distinct
functions. A great deal of our knowledge of the molecular and functional
properties of KARs comes from their study in the hippocampus. This review aims at
summarising the functions of KARs in the regulation of the activity of
hippocampal synaptic circuits at the adult stage and throughout development. We
focus on the variety of roles played by KARs in physiological conditions of
activation, at pre- and postsynaptic sites, in different cell types and through
either metabotropic or ionotropic actions. Finally, we present some of the few
attempts to link the role of KARs in the regulation of local hippocampal circuits
to the behavioural functions of the hippocampus in health and diseases.
© 2014 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
DOI: 10.1111/ejn.12590
PMID: 24738709 [Indexed for MEDLINE]