Integrated device for combined optical neuromodulation and electrical recording for chronic in vivo applications.

Jing Wang, Fabien Wagner, David A Borton, Jiayi Zhang, Ilker Ozden, Rebecca D Burwell, Arto V Nurmikko, Rick van Wagenen, Ilka Diester, Karl Deisseroth
J. Neural Eng.. 2011-12-07; 9(1): 016001
DOI: 10.1088/1741-2560/9/1/016001

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1. J Neural Eng. 2012 Feb;9(1):016001. doi: 10.1088/1741-2560/9/1/016001. Epub 2011
Dec 7.

Integrated device for combined optical neuromodulation and electrical recording
for chronic in vivo applications.

Wang J(1), Wagner F, Borton DA, Zhang J, Ozden I, Burwell RD, Nurmikko AV, van
Wagenen R, Diester I, Deisseroth K.

Author information:
(1)Department of Physics, Brown University, Providence, RI, USA.

Studying brain function and its local circuit dynamics requires neural interfaces
that can record and stimulate the brain with high spatiotemporal resolution.
Optogenetics, a technique that genetically targets specific neurons to express
light-sensitive channel proteins, provides the capability to control central
nervous system neuronal activity in mammals with millisecond time precision. This
technique enables precise optical stimulation of neurons and simultaneous
monitoring of neural response by electrophysiological means, both in the vicinity
of and distant to the stimulation site. We previously demonstrated, in vitro, the
dual capability (optical delivery and electrical recording) while testing a novel
hybrid device (optrode-MEA), which incorporates a tapered coaxial optical
electrode (optrode) and a 100 element microelectrode array (MEA). Here we report
a fully chronic implant of a new version of this device in ChR2-expressing rats,
and demonstrate its use in freely moving animals over periods up to 8 months. In
its present configuration, we show the device delivering optical excitation to a
single cortical site while mapping the neural response from the surrounding 30
channels of the 6 × 6 element MEA, thereby enabling recording of optically
modulated single-unit and local field potential activity across several
millimeters of the neocortical landscape.

DOI: 10.1088/1741-2560/9/1/016001
PMID: 22156042 [Indexed for MEDLINE]


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