Hippocampal and striatal [3H]5-HT reuptake under acute stressors in two rat strains differing for their emotivity
Neuroscience Letters. 2000-07-01; 288(3): 246-248
DOI: 10.1016/S0304-3940(00)01246-5
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Martin C(1), Duclos M, Mormède P, Manier G, Chaouloff F.
Author information:
(1)Laboratoire de Physiologie de l’Exercice Musculaire et du Sport, Université
Bordeaux II, 33076, Bordeaux, France.
Spontaneously hypertensive rats and Lewis rats differ in their anxiety levels
and in their serotonergic and corticotropic responses to stress. Since the 5-HT
transporter plays a key role in 5-HT neurotransmission, we have analyzed whether
hippocampal and/or striatal [(3)H]5-HT reuptake kinetics are altered by stress
in a strain-dependent manner. It was found that forced swimming, treadmill
running, or restraint for 30 min affected neither hippocampal nor striatal
[(3)H]5-HT reuptake K(m) and V(max) values in the two rat strains. This study,
which is the first to examine the impact of acute stress on [(3)H]5-HT reuptake
with respect to the nature of the stressor, the brain region analyzed, and the
rat strain, could reinforce the hypothesis that extracellular 5-HT levels during
stress are representative of 5-HT release.