High frequency stimulation of the entopeduncular nucleus sets the cortico-basal ganglia network to a new functional state in the dystonic hamster.
Neurobiology of Disease. 2009-09-01; 35(3): 399-405
DOI: 10.1016/j.nbd.2009.05.022
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1. Neurobiol Dis. 2009 Sep;35(3):399-405. doi: 10.1016/j.nbd.2009.05.022. Epub 2009
Jun 6.
High frequency stimulation of the entopeduncular nucleus sets the cortico-basal
ganglia network to a new functional state in the dystonic hamster.
Reese R(1), Charron G, Nadjar A, Aubert I, Thiolat ML, Hamann M, Richter A,
Bezard E, Meissner WG.
Author information:
(1)Université Victor Segalen – Bordeaux 2, Centre National de la Recherche
Scientifique, Bordeaux Institute of Neuroscience, UMR 5227, 33076 Bordeaux Cedex,
France.
High frequency stimulation (HFS) of the internal pallidum is effective for the
treatment of dystonia. Only few studies have investigated the effects of
stimulation on the activity of the cortex-basal ganglia network. We here assess
within this network the effect of entopeduncular nucleus (EP) HFS on the
expression of c-Fos and cytochrome oxidase subunit I (COI) in the dt(sz)-hamster,
a well-characterized model of paroxysmal dystonia. In dt(sz)-hamsters, we
identified abnormal activity in motor cortex, basal ganglia and thalamus. These
structures have already been linked to the pathophysiology of human dystonia.
EP-HFS (i) increased striatal c-Fos expression in controls and dystonic hamsters
and (ii) reduced thalamic c-Fos expression in dt(sz)-hamsters. EP-HFS had no
effect on COI expression. The present results suggest that EP-HFS induces a new
network activity state which may improve information processing and finally
reduces the severity of dystonic attacks in dt(sz)-hamsters.
DOI: 10.1016/j.nbd.2009.05.022
PMID: 19501651 [Indexed for MEDLINE]