Effects of adrenalectomy and corticosterone replacement on diurnal [3H]citalopram binding in rat midbrain
Neuroscience Letters. 1997-01-01; 222(2): 127-131
DOI: 10.1016/S0304-3940(97)13351-1
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1. Neurosci Lett. 1997 Jan 31;222(2):127-31. doi: 10.1016/s0304-3940(97)13351-1.
Effects of adrenalectomy and corticosterone replacement on diurnal
[3H]citalopram binding in rat midbrain.
Kulikov A(1), Mormède P, Chaouloff F.
Author information:
(1)INSERM CJF 94-05, INRA, Institut F. Magendie, Bordeaux, France.
Corticosteroids modulate the expression and/or functions of several serotonin
(5-hydroxytryptamine; 5-HT) receptors. Conversely, analyses of the effects of
corticosteroids upon 5-HT reuptake systems have been scarce and contradictory.
Herein, the diurnal rhythm of midbrain [3H]citalopram binding to 5-HT
transporters was analysed in sham and 11 day adrenalectomised rats. In addition,
adrenalectomised rats were either complemented or not with corticosterone
pellets (12.5-200 mg). Analyses of body weight increases and plasma
adrenocorticotropic and corticosterone levels indicated that the protocol
allowed the stimulation of mineralocorticoid receptors (MRs; 12.5 mg pellets) or
the stimulation of both MRs and glucocorticoid receptors (GRs; 50-200 mg
pellets). However, besides the observation of a slight, but significant diurnal
(corticosteroid-independent) rhythm in 5-HT transporter binding (morning >
evening), it was found that neither adrenalectomy nor corticosteroid receptor
stimulation affected midbrain [3H]citalopram binding.
DOI: 10.1016/s0304-3940(97)13351-1
PMID: 9111745 [Indexed for MEDLINE]