Early prenatal exposure to MPTP does not affect nigrostrial neurons in macaque monkey.
Synapse. 2015-12-04; 70(2): 52-56
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1. Synapse. 2016 Feb;70(2):52-6. doi: 10.1002/syn.21876. Epub 2015 Dec 4.
Early prenatal exposure to MPTP does not affect nigrostrial neurons in macaque
Bourdenx M(1)(2), Dovero S(1)(2), De Deurwaerdère P(1)(2), Li Q(3)(4), Bezard
(1)Université De Bordeaux, Institut Des Maladies Neurodégénératives, Bordeaux,
UMR 5293, France.
(2)Institut Des Maladies Neurodégénératives, CNRS, Bordeaux, UMR 5293, France.
(3)Institute of Laboratory Animal Sciences, Chinese Academy of Medical Science
and Peking Union Medical College, Beijing, China.
(4)Motac Neuroscience, Manchester, UK.
The discovery of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a toxin
that induces parkinsonism in both human and primate, has prompted the search for
environmental toxins potentially responsible for idiopathic Parkinson’s disease
(PD). The present study reports the ultimate effects of MPTP intoxication of a
female macaque monkey, which unraveled to be pregnant after parkinsonism had
developed, upon its fetus. Detailed examination of the offpsring nigrostriatal
pathway showed that tyrosine hydroxylase immunoreactivity in caudate-putamen
nuclei and substantia nigra compacta (SNc) was not different from an age-matched
control. Biochemical analysis of the tissue content of dopaminergic markers
further suggested modification of metabolism in the MPTP-exposed monkey. These
data suggest that early prenatal intoxication does not destroy nigrostriatal
neurons, most likely because dopamine neurons had not developed yet when exposed
© 2015 Wiley Periodicals, Inc.
PMID: 26584009 [Indexed for MEDLINE]