Early-life factors associated with increased risk of disability pension in the national real-world schizophrenia FACE-SZ cohort study.
Eur Arch Psychiatry Clin Neurosci. 2022-03-25; 272(7): 1379-1384
DOI: 10.1007/s00406-021-01364-7
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1. Eur Arch Psychiatry Clin Neurosci. 2022 Oct;272(7):1379-1384. doi:
10.1007/s00406-021-01364-7. Epub 2022 Mar 25.
Early-life factors associated with increased risk of disability pension in the
national real-world schizophrenia FACE-SZ cohort study.
Fond G(1)(2), Dubreucq J(3)(4), de Verville PLS(3)(5), Godin O(3),
Andrieu-Haller C(3)(5), Berna F(3)(6), Aouizerate B(3)(7)(8), Capdevielle
D(3)(9), Chereau I(3)(10), Clauss-Kobayashi J(3)(6), Coulon N(3)(4), Dorey
JM(3)(11), Dubertret C(3)(12), Mallet J(3)(12), Misdrahi D(3)(7)(13), Passerieux
C(3)(14)(15), Rey R(3)(11), Pignon B(16), Schürhoff F(3)(16), Urbach
M(3)(14)(15), Llorca PM(3)(10), Lançon C(3)(5), Boyer L(3)(5); FACE-SZ.
(FondaMental Academic Centers of Expertise for Schizophrenia) group.
Author information:
(1)Fondation FondaMental, Créteil, France. .
(2)Faculté de Médecine – Secteur Timone, AP-HM, Aix-Marseille Univ, EA 3279:
CEReSS-Centre d’Etude et de Recherche sur les Services de Santé et la Qualité de
Vie, 27 Boulevard Jean Moulin, 13005, Marseille, France.
.
(3)Fondation FondaMental, Créteil, France.
(4)Centre Référent de Réhabilitation Psychosociale, CH Alpes Isère, Grenoble,
France.
(5)Faculté de Médecine – Secteur Timone, AP-HM, Aix-Marseille Univ, EA 3279:
CEReSS-Centre d’Etude et de Recherche sur les Services de Santé et la Qualité de
Vie, 27 Boulevard Jean Moulin, 13005, Marseille, France.
(6)Fédération de Médecine Translationnelle de Strasbourg, Hôpitaux
Universitaires de Strasbourg, Université de Strasbourg, INSERM U1114,
Strasbourg, France.
(7)Pôle de Psychiatrie Générale et Universitaire, Centre Hospitalier Charles
Perrens, Université de Bordeaux, CNRS UMR 5287-INCIA, 33076, Bordeaux, France.
(8)INRA, NutriNeuro, University of Bordeaux, U1286, F-33076, Bordeaux, France.
(9)Service Universitaire de Psychiatrie Adulte, Hôpital la Colombière, CHRU
Montpellier, IGF, Univ. Montpellier, CNRS, INSERM, Montpellier, France.
(10)Université Clermont Auvergne, CMP-B, CHU, CNRS, Clermont Auvergne INP,
Institut Pascal, 63000, Clermont-Ferrand, France.
(11)INSERM U1028, CNRS UMR5292, Centre de Recherche en Neurosciences de Lyon,
Université Claude Bernard Lyon 1, Equipe PSYR2, Centre Hospitalier Le Vinatier,
Pole Est, 95 bd Pinel, BP 30039, 69678, Bron Cedex, France.
(12)Department of Psychiatry, Université de Paris, AP-HP, Louis Mourier
Hospital, Colombes, INSERM UMR 1266, Paris, France.
(13)CNRS UMR 5287-INCIA, Bordeaux, France.
(14)Service Universitaire de Psychiatrie d’Adultes et d’Addictologie, Centre
Hospitalier de Versailles, 177 rue de Versailles, 78157, Le Chesnay, France.
(15)DisAP-DevPsy-CESP, INSERM UMR1018, Université Paris-Saclay, Université
Versailles Saint-Quentin-En-Yvelines, 94807, Villejuif, France.
(16)Université Paris Est Creteil (UPEC), AP-HP, Hôpitaux Universitaires « H.
Mondor », DMU IMPACT, INSERM, IMRB, Translational Neuropsychiatry, Fondation
FondaMental, 94010, Creteil, France.
Among severe psychiatric disorders, schizophrenia has one of the highest impacts
on professional and personal functioning with important indirect costs including
disability pension allowance for the patients with the more severe forms of
schizophrenia. To explore early-life factors associated with disability pension
in schizophrenia. 916 patients were consecutively recruited at a national level
in 10 expert centers and received a comprehensive standardized evaluation. Their
disability pension status and early-life variables were reported from medical
records and validated scales. Eight factors were explored: age, male sex,
parental history of severe mental illness, childhood trauma exposure, education
level, childhood ADHD, early age at schizophrenia onset and duration of
untreated psychosis. 739 (80.7%) participants received a disability pension. In
the multivariate model, early age at schizophrenia onset and low education level
were associated with disability pension independently of age and sex while no
significant association was found for parent history of severe mental illness,
childhood trauma, childhood ADHD or duration of untreated psychosis. Low
education level and early age at schizophrenia onset seem the best predictors of
increased risk of disability pension in schizophrenia.
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
DOI: 10.1007/s00406-021-01364-7
PMID: 35333961 [Indexed for MEDLINE]