Cyclic AMP-modulated potassium channels in murine B cells and their precursors

D Choquet, P Sarthou, D Primi, P. Cazenave, H Korn
Science. 1987-03-06; 235(4793): 1211-1214
DOI: 10.1126/science.2434998

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A voltage-dependent potassium current (the delayed rectifier) has been found in
murine B cells and their precursors with the whole-cell patch-clamp technique.
The type of channel involved in the generation of this current appears to be
present throughout all stages of pre-B-cell differentiation, since it is detected
in pre-B cell lines infected with Abelson murine leukemia virus; these cell lines
represent various phases of B-cell development. Thus, the presence of this
channel is not obviously correlated with B-cell differentiation. Although blocked
by Co2+, the channel, or channels, does not appear to be activated by Ca2+ entry.
It is, however, inactivated by high intracellular Ca2+ concentrations. In
addition, elevation of intracellular adenosine 3′, 5′-monophosphate induces at
all potentials a rapid decrease in the peak potassium conductance and increased
rates of activation and inactivation. Therefore, potassium channels can be
physiologically modulated by second messengers in lymphocytes.


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