Contribution of pre-synaptic mechanisms to L-DOPA-induced dyskinesia.
Neuroscience. 2011-12-01; 198: 245-251
DOI: 10.1016/j.neuroscience.2011.07.070
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1. Neuroscience. 2011 Dec 15;198:245-51. doi: 10.1016/j.neuroscience.2011.07.070.
Epub 2011 Aug 5.
Contribution of pre-synaptic mechanisms to L-DOPA-induced dyskinesia.
Carta M(1), Bezard E.
Author information:
(1)Neurobiology Unit, Department of Experimental Medical Science, Lund
University, BMC A11, Solvegatan 17, 22184 Lund, Sweden.
Positron emission tomography (PET) imaging studies have shown that peak-dose
dyskinesia is associated to abnormally high levels of synaptic dopamine (DA) in
the caudate-putamen of dyskinetic L-DOPA-treated patients. High striatal
extracellular DA levels have also been found in dyskinetic 6-OHDA-lesioned rats
as compared to non-dyskinetic ones, suggesting that extracellular DA levels may
play a key role in the induction of dyskinesia. In this article we review the
evidences pointing to the serotonin system as the primary cause for the
abnormally high levels of L-DOPA-derived extracellular DA in Parkinson’s disease,
and we discuss the feasibility of a therapeutic approach targeting this system.
Copyright © 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.neuroscience.2011.07.070
PMID: 21840375 [Indexed for MEDLINE]