Chronic administration of DL-allyl-glycine into the neostriatum, disorganises the firing modes of the nigral dopaminergic neurons in the rat
Neuroscience Letters. 1997-04-01; 226(1): 21-24
DOI: 10.1016/S0304-3940(97)00236-X
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1. Neurosci Lett. 1997 Apr 18;226(1):21-4. doi: 10.1016/s0304-3940(97)00236-x.
Chronic administration of DL-allyl-glycine into the neostriatum, disorganises
the firing modes of the nigral dopaminergic neurons in the rat.
Bioulac B(1), Benazzouz A, Burbaud P, Gross C.
Author information:
(1)Laboratoire de Neurophysiologie, CNRS UMR 5543, Université de BordeauxII,
France.
Nigral dopaminergic (DA) neurons have been reported to fire according to three
modes: very regular (pacemaker 42%) irregular (random 46%) and bursty (12%). The
switch from simple spiking mode (pacemaker or random) to bursty firing would
correspond to an increase in DA release necessary for the performance of a new
motor act. As nigral DA cells are impinged upon by a high percentage of
GABAergic afferents we blocked striatal GABAergic output neurons by chronic
administration into the neostriatum of allyl-glycine, a glutamic acid
decarboxylase (GAD) inhibitor. After treatment, rats presented hyperkinesia and
hypertonia on the injected side and recordings showed a drastic change in the
percentage distribution of nigral DA cell discharge patterns; 85% were ‘random’,
12% ‘pacemaker’ and 3% bursty. Such a disturbance, by impeding adapted DA
release, may account for the hyperkinetic and dystonic disorders observed.
DOI: 10.1016/s0304-3940(97)00236-x
PMID: 9153632 [Indexed for MEDLINE]