A team for Frédéric Gambino at IINS

Frédéric Gambino had been in Yann Humeau’s team since November 2014. 

He becomes group leader of the team “Neuronal coding of choice and action-selection during decision-making in behaving mice” .

Frédéric Gambino then succeeded in getting an ERC starting grant (2016-2021). His “NEUROGOAL” project is exploring the causal effect of learning during a complex decision task but also, and for the first time, when the mouse learns to perform the task. To achieve this goal, the team of Frédéric Gambino is developing here in Bordeaux unique tools at the cutting edge of technology and innovation.

His team is part of a rare imaging infrastructure in vivo in Europe and in the world. This does not only underpin innovative research but also leads its development and creates a highly attractive climate for world-class postdocs and senior researchers.

Frédéric Gambino’s research goal is to understand how neuronal networks of behaving animals modulate the structure of their synaptic connections in response to learning, and how this process regulates the dynamics of representations that drive complex behaviors such as associative fear learning, decision-making, and action selection.  Lire  sa page  sur le site de l’IINS

1. Gambino F, Pagès S, Kehayas V, Baptista D, Tatti R, Carleton A, Holtmaat A. Sensory-evoked long-term synaptic potentiation driven by dendritic plateau potentials in vivo. Nature (2014); 515:116-9

2. Gambino F and Holtmaat A. Spike-timing dependent potentiation of sensory surround in the somatosensory cortex is facilitated by deprivation-mediated disinhibition. Neuron (2012), 75:490-502

3. Pouchelon G, Gambino F, Bellone C, Lüscher C, Holtmaat A, Jabaudon D. Modality specific thalamo-cortical inputs instruct the identity of postsynaptic L4 neurons. Nature (2014), 511:471-4.

4. Fourcaudot E*, Gambino F*, Casassus G, Poulain B, Humeau Y & Lüthi A. L-type voltage-dependent Ca(2+) channels mediate expression of presynaptic LTP in amygdala. Nat. Neurosci (2009), 12:1093-95. (co-first author)

5. Gambino F, Pavlowsky A, Béglé A, Dupont J, Bahi N, Courjaret R, Gardette R, Hadjkacem H, Skala H, Poulain B, Chelly J, Vitale N & Humeau Y. IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca2+-channel and neurite elongation. PNAS (2007), 104:9063-68

Frédéric Gambino, PhD, CNRS Group leader / IINS / Bordeaux Neurocampus

Dernière mise à jour le 04.07.2016

01/07/16