Hypothalamic POMC Neurons Gate the Fear-Feeding Trade-Off
Cristina Miralpeix (Cota team) and Abel Eraso-Pichot (Marsicano team), from the Neurocentre Magendie (Univ. Bordeaux / Inserm), have just published a study in Advanced Science on how the brain arbitrates between feeding and staying safe. When confronted with potential threats, hungry animals must continually arbitrate between feeding and defensive behaviors. The authors show that hypothalamic POMC neurons engage CRH-expressing stress circuits and downstream hormonal responses to coordinate the selection between these competing behaviors. CB1 receptor signaling in POMC neurons modulates this process, biasing behavior toward defensive responses over feeding.
Article
Hypothalamic POMC Neurons Gate the Fear-Feeding Trade-Off
Cristina Miralpeix#1 , Abel Eraso-Pichot #1, Vincent Simon1, Victor Jouque1, Melissa Sadallah1 , Samantha Clark1, Philippe Zizzari1, Urszula Skupio1 , Ana Covelo1 , Nathalie Dupuy1, Jean Charles Nicolas1 , Astrid Cannich1, Thierry Leste-Lasserre1, Guillaume Laplagne1, Carmelo Quarta1, Giovanni Marsicano1, Daniela Cota1
1 University of Bordeaux, INSERM, Neurocentre Magendie, U1215, Bordeaux, France.
# Contributed equally.
doi: 10.1002/advs.78379
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.78379
Publication: 22/10/26
Last update 22/10/26
Last update 22/10/26