TREMendous 2 Be Social.
Immunity. 2018-05-01; 48(5): 842-843
DOI: 10.1016/j.immuni.2018.04.034
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1. Immunity. 2018 May 15;48(5):842-843. doi: 10.1016/j.immuni.2018.04.034.
TREMendous 2 Be Social.
Calcagno N(1), Baufeld C(1), Madore C(1), Butovsky O(2).
Author information:
(1)Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham
and Women’s Hospital, Harvard Medical School, Boston, MA, USA.
(2)Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham
and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Evergrande Center
for Immunologic Diseases, Brigham and Women’s Hospital, Harvard Medical School,
Boston, MA, USA. Electronic address: .
Comment on
Immunity. 2018 May 15;48(5):979-991.e8.
TREM2 is known for its role in microglial phagocytosis and in neurodegenerative
diseases. In this issue of Immunity, Filipello et al. (2018) show that microglial
TREM2 is required for synaptic pruning in early development. TREM2-deficient mice
show altered social behavior in adulthood, linking TREM2 to neurodevelopmental
disease.
Copyright © 2018 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.immuni.2018.04.034
PMCID: PMC8152169
PMID: 29768169 [Indexed for MEDLINE]