Synapse-specific and plasticity-regulated AMPA receptor mobility tunes synaptic integration
Neuron. 2026-02-01; :
DOI: 10.1016/j.neuron.2025.12.004
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https://www.bordeaux-neurocampus.fr/12569
Nowacka A(1), Getz AM(2), Zieger HL(1), Malivert M(3), Bessa-Neto D(1), Augusto
E(1), Breillat C(1), Daburon S(1), Lemoigne C(1), Marais S(4), Ducros M(4),
Favereaux A(1), Penn AC(5), Naud R(6), Sainlos M(1), Choquet D(7).
Author information:
(1)Interdisciplinary Institute for Neuroscience (IINS), Université de Bordeaux,
UMR 5297 CNRS, 33076 Bordeaux, France.
(2)Interdisciplinary Institute for Neuroscience (IINS), Université de Bordeaux,
UMR 5297 CNRS, 33076 Bordeaux, France; Bordeaux Imaging Center (BIC), Université
de Bordeaux, UMS 3420 CNRS, US 4 INSERM, 33076 Bordeaux, France; Department of
Functional Genomics, Center for Neurogenomics and Cognitive Research (CNCR),
Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the Netherlands. Electronic
address: .
(3)Department of Functional Genomics, Center for Neurogenomics and Cognitive
Research (CNCR), Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the
Netherlands.
(4)Bordeaux Imaging Center (BIC), Université de Bordeaux, UMS 3420 CNRS, US 4
INSERM, 33076 Bordeaux, France.
(5)Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton
BN1 9QG, UK.
(6)Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa,
ON K1H 8M5, Canada.
(7)Interdisciplinary Institute for Neuroscience (IINS), Université de Bordeaux,
UMR 5297 CNRS, 33076 Bordeaux, France; Bordeaux Imaging Center (BIC), Université
de Bordeaux, UMS 3420 CNRS, US 4 INSERM, 33076 Bordeaux, France. Electronic
address: .
Synaptic responses adapt on millisecond-to-second timescales through short-term
plasticity (STP), a key process that filters and transforms neuronal
information. While STP is classically ascribed to presynaptic release
mechanisms, postsynaptic receptor properties-particularly desensitization and
surface diffusion-also shape synaptic responses. Here, we dissect pre- and
postsynaptic contributions to synaptic adaptation using molecular tools to
visualize glutamate release and manipulate AMPA receptor (AMPAR) diffusion in
intact circuits. We find that synaptic gain during STP is tuned by
synapse-specific regulation of AMPAR biophysics and diffusion-trapping. These
features are determined constitutively by auxiliary subunit profiles and
dynamically by activity-dependent signaling engaged during long-term plasticity.
With modeling, we quantified how short-term synaptic dynamics are impacted by
postsynaptic regulation of filtering properties, which broadened heterogeneity
of filtering timescales to refine temporal selectivity in synaptic networks. By
augmenting desensitization-mediated synaptic depression, AMPAR
diffusion-trapping emerges as a fundamental regulatory mechanism of postsynaptic
integration and circuit-level information processing.
Copyright © 2025 The Author(s). Published by Elsevier Inc. All rights reserved.
DOI: 10.1016/j.neuron.2025.12.004
PMID: 41643663
Conflict of interest statement: Declaration of interests The authors declare no
competing interests.