Spike-timing-dependent potentiation of sensory surround in the somatosensory cortex is facilitated by deprivation-mediated disinhibition
Neuron. 2012-08-01; 75(3): 490-502
DOI: 10.1016/j.neuron.2012.05.020
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1. Neuron. 2012 Aug 9;75(3):490-502. doi: 10.1016/j.neuron.2012.05.020.
Spike-timing-dependent potentiation of sensory surround in the somatosensory
cortex is facilitated by deprivation-mediated disinhibition.
Gambino F(1), Holtmaat A.
Author information:
(1)Department of Basic Neurosciences, Faculty of Medicine, University of Geneva,
CMU, 1 rue Michel Servet, 1211 Geneva, Switzerland.
Functional maps in the cerebral cortex reorganize in response to changes in
experience, but the synaptic underpinnings remain uncertain. Here, we demonstrate
that layer (L) 2/3 pyramidal cell synapses in mouse barrel cortex can be
potentiated upon pairing of whisker-evoked postsynaptic potentials (PSPs) with
action potentials (APs). This spike-timing-dependent long-term potentiation
(STD-LTP) was only effective for PSPs evoked by deflections of a whisker in the
neuron’s receptive field center, and not its surround. Trimming of all except two
whiskers rapidly opened the possibility to drive STD-LTP by the spared surround
whisker. This facilitated STD-LTP was associated with a strong decrease in the
surrounding whisker-evoked inhibitory conductance and partially occluded
picrotoxin-mediated LTP facilitation. Taken together, our data demonstrate that
sensory deprivation-mediated disinhibition facilitates STD-LTP from the sensory
surround, which may promote correlation- and experience-dependent expansion of
receptive fields.
Copyright © 2012 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.neuron.2012.05.020
PMID: 22884332 [Indexed for MEDLINE]