Regulation of hippocampal postnatal and adult neurogenesis by adenosine A _2A receptor: Interaction with brain‐derived neurotrophic factor

1. Stem Cells. 2021 Oct;39(10):1362-1381. doi: 10.1002/stem.3421. Epub 2021 Jun
7.

Regulation of hippocampal postnatal and adult neurogenesis by adenosine A(2A)
receptor: Interaction with brain-derived neurotrophic factor.

Ribeiro FF(1)(2), Ferreira F(1)(2), Rodrigues RS(1)(2), Soares R(1)(2)(3), Pedro
DM(1)(2), Duarte-Samartinho M(1)(2), Aroeira RI(1)(2), Ferreiro E(4), Valero
J(5)(6)(7), Solá S(3), Mira H(8)(9), Sebastião AM(1)(2), Xapelli S(1)(2).

Author information:
(1)Instituto de Farmacologia e Neurociências, Faculdade de Medicina,
Universidade de Lisboa, Lisbon, Portugal.
(2)Instituto de Medicina Molecular João Lobo Antunes (iMM, JLB), Faculdade de
Medicina, Universidade de Lisboa, Lisbon, Portugal.
(3)iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa, Lisbon,
Portugal.
(4)Center for Neuroscience and Cell Biology (CNC), University of Coimbra,
Coimbra, Portugal.
(5)Laboratory of Glial Cell Biology, Achucarro Basque Center for Neuroscience,
Leioa, Spain.
(6)Ikerbasque Foundation, Bilbao, Spain.
(7)University of the Basque Country EHU/UPV, Leioa, Spain.
(8)Instituto de Salud Carlos III (ISCIII), Majadahonda, Madrid, Spain.
(9)Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain.

Adenosine A2A receptor (A2A R) activation modulates several brain processes,
ranging from neuronal maturation to synaptic plasticity. Most of these actions
occur through the modulation of the actions of the neurotrophin brain-derived
neurotrophic factor (BDNF). In this work, we studied the role of A2A Rs in
regulating postnatal and adult neurogenesis in the rat hippocampal dentate gyrus
(DG). Here, we show that A2A R activation with CGS 21680 promoted neural stem
cell self-renewal, protected committed neuronal cells from cell death and
contributed to a higher density of immature and mature neuronal cells,
particularly glutamatergic neurons. Moreover, A2A R endogenous activation was
found to be essential for BDNF-mediated increase in cell proliferation and
neuronal differentiation. Our findings contribute to further understand the role
of adenosinergic signaling in the brain and may have an impact in the
development of strategies for brain repair under pathological conditions.

© 2021 AlphaMed Press.

DOI: 10.1002/stem.3421
PMID: 34043863 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus