Rui Rodrigues

Publications

• Cannabinoid and adenosine A_2A receptor crosstalk regulates postnatal and adult hippocampal neurogenesis
  Rui S. Rodrigues, Adam Armada‐Moreira, Laura Gómez‐Acero, Filipa F. Ribeiro, Francisco M. Mouro, Ana M. Sebastião, Francisco Ciruela, Ester Aso, Sara Xapelli.
  British Journal of Pharmacology. 2026-06-22.
  10.1111/bph.70466
• Towards Mechanism‐Informed Treatments for Mental Health
  Iker Bengoetxea de Tena, Farhanah Nabilah Sallie, Arvie Rodriguez Abiero, Beatrice Rizzi, Leandro Gabriel Champarini, Elisa Corti, Gianluca Masella, Ariel L. Dunn, Luisa Bandeira Binder, Tyler J. Wenzel, Agustin I. Robles, Roberta G. Anversa, Cécilia Tremblay, Aliance Romain Fokoua, Randriely Merscher Sobreira de Lima, Mateus D'Ávila, Trang T. T. Truong, Jessica C. Pierce, Rui S. Rodrigues, Luis Dinamarca‐Villarroel, Felipe Borges Almeida, Aino‐Kaisa Piironen, Andrey F. L. Aguiar, Andrés M. Jaramillo, Lucas Santos, Anja de Lange, David J. Nutt, Andrew J. Lawrence.
  Journal of Neurochemistry. 2026-05-01. 170(5)
  10.1111/jnc.70477
• Cannabidivarin mitigates motor and cognitive impairments in a female mouse model of Rett syndrome
  Diogo M. Lourenço, Svitlana Zavalko, Ana Laura Duarte, Sónia Sá-Santos, Joana M. Mateus, Rui S. Rodrigues, Catarina Miranda-Lourenço, Francisco M. Mouro, Ricardo Viais, Ana M. Sebastião, Susana Solá, Maria José Diógenes, Sara Xapelli.
  Life Sciences. 2025-10-01. 378 : 123846.
  10.1016/j.lfs.2025.123846
• Potentiation of mitochondrial function by mitoDREADD-Gs reverses pharmacological and neurodegenerative cognitive impairment in mice
  Antonio C. Pagano Zottola, Rebeca Martín-Jiménez, Gianluca Lavanco, Geneviève Hamel-Côté, Carla Ramon-Duaso, Rui S. Rodrigues, Yamuna Mariani, Mehtab Khan, Filippo Drago, Stephanie Jean, Itziar Bonilla-Del Río, Daniel Jimenez-Blasco, Jon Egaña-Huguet, Abel Eraso-Pichot, Sandra Beriain, Astrid Cannich, Laura Vidal-Palencia, Rosmara Infantino, Francisca Julio-Kalajzić, Doriane Gisquet, Ania Goncalves, Inas Al-Younis, Yann Baussan, Stephane Duvezin-Caubet, Anne Devin, Edgar Soria-Gomez, Nagore Puente, Juan P. Bolaños, Pedro Grandes, Sandrine Pouvreau, Arnau Busquets-Garcia, Giovanni Marsicano, Luigi Bellocchio, Etienne Hebert-Chatelain.
  Nat Neurosci. 2025-08-11. 28(9) : 1844-1857.
  10.1038/s41593-025-02032-y
• The Effects of Exercise‐Associated Factors on Hippocampal Progenitor Cell Dynamics Are Mediated by Cannabinoid Type 2 Receptors
  R. S. Rodrigues, J. B. Moreira, P. Dias, A. M. Sebastião, S. Xapelli.
  Journal of Neurochemistry. 2025-05-01. 169(5)
  10.1111/jnc.70091
• (Re)building the nervous system: A review of neuron–glia interactions from development to disease
  Matthew D. Demmings, Luana da Silva Chagas, Marianela E. Traetta, Rui S. Rodrigues, Maria Florencia Acutain, Evgeny Barykin, Ashok Kumar Datusalia, Liliana German‐Castelan, Vanesa S. Mattera, Pedzisai Mazengenya, Cecilia Skoug, Hisashi Umemori.
  Journal of Neurochemistry. 2024-12-16. 169(1)
  10.1111/jnc.16258
• Correction: Santos et al. The Mitochondrial Antioxidant Sirtuin3 Cooperates with Lipid Metabolism to Safeguard Neurogenesis in Aging and Depression. Cells 2022, 11, 90
  Sónia Santos, João Moreira, Márcia Costa, Rui Rodrigues, Ana Sebastião, Sara Xapelli, Susana Solá.
  Cells. 2024-07-24. 13(15) : 1239.
  10.3390/cells13151239
• Cannabinoid type 2 receptor inhibition enhances the antidepressant and proneurogenic effects of physical exercise after chronic stress
  R. S. Rodrigues, J. B. Moreira, J. M. Mateus, A. Barateiro, S. L. Paulo, S. H. Vaz, D. M. Lourenço, F. F. Ribeiro, R. Soares, E. Loureiro-Campos, P. Bielefeld, A. M. Sebastião, A. Fernandes, L. Pinto, C. P. Fitzsimons, S. Xapelli.
  Translational Psychiatry. 2024-03-30. 14(1)
  10.1038/s41398-024-02877-0
• Unravelling a novel role for cannabidivarin in the modulation of subventricular zone postnatal neurogenesis
  Diogo M. Lourenço, Rita Soares, Sónia Sá-Santos, Joana M. Mateus, Rui S. Rodrigues, João B. Moreira, Sandra H. Vaz, Ana M. Sebastião, Susana Solá, Sara Xapelli.
  European Journal of Pharmacology. 2023-11-01. 959 : 176079.
  10.1016/j.ejphar.2023.176079
• Striatopallidal cannabinoid type-1 receptors mediate amphetamine-induced sensitization
  Yamuna Mariani, Ana Covelo, Rui S. Rodrigues, Francisca Julio-Kalajzić, Antonio C. Pagano Zottola, Gianluca Lavanco, Michela Fabrizio, Doriane Gisquet, Filippo Drago, Astrid Cannich, Jerome Baufreton, Giovanni Marsicano, Luigi Bellocchio.
  Current Biology. 2023-11-01. 33(22) : 5011-5022.e6.
  10.1016/j.cub.2023.09.075
• Type‐1 cannabinoid receptors and their ever‐expanding roles in brain energy processes
  Ignacio Fernández‐Moncada, Rui S. Rodrigues, Unai B. Fundazuri, Luigi Bellocchio, Giovanni Marsicano.
  Journal of Neurochemistry. 2023-07-28.
  10.1111/jnc.15922
• Cannabinoid type 2 receptor inhibition enhances the antidepressant and proneurogenic effects of physical exercise after chronic stress
  RS Rodrigues, JB Moreira, SH Vaz, A Barateiro, SL Paulo, JM Mateus, DM Lourenço, FF Ribeiro, E Loureiro-Campos, P Bielefeld, A Fernandes, AM Sebastião, L Pinto, CP Fitzsimons, S Xapelli.
  . 2023-04-24.
  10.1101/2023.04.24.538087
• The Mitochondrial Antioxidant Sirtuin3 Cooperates with Lipid Metabolism to Safeguard Neurogenesis in Aging and Depression
  Sónia Sá Santos, João B. Moreira, Márcia Costa, Rui S. Rodrigues, Ana M. Sebastião, Sara Xapelli, Susana Solá.
  Cells. 2021-12-29. 11(1) : 90.
  10.3390/cells11010090
• High Caloric Diet Induces Memory Impairment and Disrupts Synaptic Plasticity in Aged Rats
  Sara L. Paulo, Catarina Miranda-Lourenço, Rita F. Belo, Rui S. Rodrigues, João Fonseca-Gomes, Sara R. Tanqueiro, Vera Geraldes, Isabel Rocha, Ana M. Sebastião, Sara Xapelli, Maria J. Diógenes.
  Current Issues in Molecular Biology. 2021-12-18. 43(3) : 2305-2319.
  10.3390/cimb43030162
• Seizing balance and success during your PhD experience
  Rui S. Rodrigues.
  European Journal of Neuroscience. 2021-08-10. 54(6) : 5907-5914.
  10.1111/ejn.15410
• Sustained Hippocampal Neural Plasticity Questions the Reproducibility of an Amyloid-β-Induced Alzheimer’s Disease Model
  Sara L. Paulo, Leonor Ribeiro-Rodrigues, Rui S. Rodrigues, Joana M. Mateus, João Fonseca-Gomes, Rita Soares, Maria J. Diógenes, Susana Solá, Ana M. Sebastião, Filipa F. Ribeiro, Sara Xapelli.
  Journal of Alzheimer's Disease. 2021-08-03. 82(3) : 1183-1202.
  10.3233/jad-201567
• Regulation of hippocampal postnatal and adult neurogenesis by adenosine A _2A receptor: Interaction with brain‐derived neurotrophic factor
  Filipa F. Ribeiro, Filipa Ferreira, Rui S. Rodrigues, Rita Soares, Diogo M. Pedro, Marta Duarte‐Samartinho, Rita I. Aroeira, Elisabete Ferreiro, Jorge Valero, Susana Solá, Helena Mira, Ana M. Sebastião, Sara Xapelli.
  STEM CELLS. 2021-06-07. 39(10) : 1362-1381.
  10.1002/stem.3421
• The neurosphere assay: an effective in vitro technique to study neural stem cells
  Sara Xapelli, Rita Soares, FilipaF Ribeiro, DiogoM Lourenço, RuiS Rodrigues, JoãoB Moreira, AnaM Sebastião, VanessaA Morais.
  Neural Regeneration Research. 2021-01-01. 16(11) : 2229.
  10.4103/1673-5374.310678
• Adult Neural Stem Cells as Promising Targets in Psychiatric Disorders
  Rui S. Rodrigues, Sara L. Paulo, João B. Moreira, Sara R. Tanqueiro, Ana M. Sebastião, Maria J. Diógenes, Sara Xapelli.
  Stem Cells and Development. 2020-08-27. 29(17) : 1099-1117.
  10.1089/scd.2020.0100
• Isolation and Expansion of Neurospheres from Postnatal (P1−3) Mouse Neurogenic Niches
  Rita Soares, Filipa F. Ribeiro, Diogo M. Lourenço, Rui S. Rodrigues, João B. Moreira, Ana M. Sebastião, Vanessa A. Morais, Sara Xapelli.
  Journal of Visualized Experiments. 2020-05-23. (159)
  10.3791/60822
• Neurogenesis and Gliogenesis: Relevance of Adenosine for Neuroregeneration in Brain Disorders
  Joana M. Mateus, Filipa F. Ribeiro, Marta Alonso-Gomes, Rui S. Rodrigues, Joana M. Marques, Ana M. Sebastião, Ricardo J. Rodrigues, Sara Xapelli.
  Journal of Caffeine and Adenosine Research. 2019-12-01. 9(4) : 129-144.
  10.1089/caff.2019.0010
• Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology
  Rui S. Rodrigues, Diogo M. Lourenço, Sara L. Paulo, Joana M. Mateus, Miguel F. Ferreira, Francisco M. Mouro, João B. Moreira, Filipa F. Ribeiro, Ana M. Sebastião, Sara Xapelli.
  Molecules. 2019-04-05. 24(7) : 1350.
  10.3390/molecules24071350
• Brain-Derived Neurotrophic Factor (BDNF) Role in Cannabinoid-Mediated Neurogenesis
  Filipa Fiel Ferreira, Filipa F. Ribeiro, Rui S. Rodrigues, Ana Maria Sebastião, Sara Xapelli.
  Frontiers in Cellular Neuroscience. 2018-11-28. 12
  10.3389/fncel.2018.00441
• Interaction between Cannabinoid Type 1 and Type 2 Receptors in the Modulation of Subventricular Zone and Dentate Gyrus Neurogenesis
  Rui S. Rodrigues, Filipa F. Ribeiro, Filipa Ferreira, Sandra H. Vaz, Ana M. Sebastião, Sara Xapelli.
  Frontiers in Pharmacology. 2017-08-10. 8
  10.3389/fphar.2017.00516