Regulation of AMPA receptor surface diffusion by PSD-95 slots
Current Opinion in Neurobiology. 2012-06-01; 22(3): 453-460
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1. Curr Opin Neurobiol. 2012 Jun;22(3):453-60. doi: 10.1016/j.conb.2011.10.010. Epub
2011 Nov 1.
Regulation of AMPA receptor surface diffusion by PSD-95 slots.
Opazo P(1), Sainlos M, Choquet D.
(1)University of Bordeaux, Interdisciplinary Institute for Neuroscience, CNRS UMR
5297, F-33000 Bordeaux, France.
Excitatory synaptic transmission is largely mediated by AMPA receptors (AMPARs)
present at the postsynaptic density. Recent studies in single molecule tracking
of AMPAR has revealed that extrasynaptic AMPARs are highly mobile and thus might
serve as a readily available pool for their synaptic recruitment during synaptic
plasticity events such as long-term potentiation (LTP). Because this hypothesis
relies on the cell’s ability to increase the number of diffusional traps or
‘slots’ at synapses during LTP, we will review a number of protein-protein
interactions that might impact AMPARs lateral diffusion and thus potentially
serve as slots. Recent studies have identified the interaction between the
AMPAR-Stargazin complex and PSD-95 as the minimal components of the diffusional
trapping slot. We will overview the molecular basis of this critical interaction,
its activity-dependent regulation and its potential contribution to LTP.
Copyright © 2011 Elsevier Ltd. All rights reserved.
PMID: 22051694 [Indexed for MEDLINE]