Prenatal exposure to alcohol does not affect radial maze learning and hippocampal mossy fiber sizes in three inbred strains of mouse
Behav Brain Funct. 2005-01-01; 1(1): 5
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1. Behav Brain Funct. 2005 Apr 22;1(1):5.
Prenatal exposure to alcohol does not affect radial maze learning and hippocampal
mossy fiber sizes in three inbred strains of mouse.
Sluyter F(1), Jamot L, Bertholet JY, Crusio WE.
(1)Laboratoire de Neurosciences Cognitives, CNRS UMR 5106 Avenue des Facultés
33405 Talence France. .
BACKGROUND: The aim of this study was to investigate the effects of prenatal
alcohol exposure on radial-maze learning and hippocampal neuroanatomy,
particularly the sizes of the intra- and infrapyramidal mossy fiber (IIPMF)
terminal fields, in three inbred strains of mice (C57BL/6J, BALB/cJ, and DBA/2J).
RESULTS: Although we anticipated a modification of both learning and IIPMF sizes,
no such effects were detected. Prenatal alcohol exposure did, however, interfere
with reproduction in C57BL/6J animals and decrease body and brain weight (in
interaction with the genotype) at adult age. CONCLUSION: Prenatal alcohol
exposure influenced neither radial maze performance nor the sizes of the IIPMF
terminal fields. We believe that future research should be pointed either at
different targets when using mouse models for Fetal Alcohol Syndrome (e.g. more
complicated behavioral paradigms, different hippocampal substructures, or other
brain structures) or involve different animal models.