Prenatal exposure to alcohol does not affect radial maze learning and hippocampal mossy fiber sizes in three inbred strains of mouse

Frans Sluyter; Laure Jamot; Jean-Yves Bertholet; Wim E Crusio

doi:10.1186/1744-9081-1-5

Prenatal exposure to alcohol does not affect radial maze learning and hippocampal mossy fiber sizes in three inbred strains of mouse

Behav Brain Funct. 2005 Apr 22;1(1):5. doi: 10.1186/1744-9081-1-5.

Authors

Frans Sluyter¹, Laure Jamot, Jean-Yves Bertholet, Wim E Crusio

Affiliation

¹ Laboratoire de Neurosciences Cognitives, CNRS UMR 5106 Avenue des Facultés 33405 Talence France. wim_crusio@yahoo.com.

Abstract

BACKGROUND: The aim of this study was to investigate the effects of prenatal alcohol exposure on radial-maze learning and hippocampal neuroanatomy, particularly the sizes of the intra- and infrapyramidal mossy fiber (IIPMF) terminal fields, in three inbred strains of mice (C57BL/6J, BALB/cJ, and DBA/2J). RESULTS: Although we anticipated a modification of both learning and IIPMF sizes, no such effects were detected. Prenatal alcohol exposure did, however, interfere with reproduction in C57BL/6J animals and decrease body and brain weight (in interaction with the genotype) at adult age. CONCLUSION: Prenatal alcohol exposure influenced neither radial maze performance nor the sizes of the IIPMF terminal fields. We believe that future research should be pointed either at different targets when using mouse models for Fetal Alcohol Syndrome (e.g. more complicated behavioral paradigms, different hippocampal substructures, or other brain structures) or involve different animal models.