Prefrontal neuronal circuits of contextual fear conditioning.
Genes, Brain and Behavior. 2014-10-27; 14(1): 22-36
DOI: 10.1111/gbb.12181
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1. Genes Brain Behav. 2015 Jan;14(1):22-36. doi: 10.1111/gbb.12181. Epub 2014 Oct
27.
Prefrontal neuronal circuits of contextual fear conditioning.
Rozeske RR(1), Valerio S, Chaudun F, Herry C.
Author information:
(1)INSERM U862, Neurocenter Magendie, Bordeaux, France.
Over the past years, numerous studies have provided a clear understanding of the
neuronal circuits and mechanisms involved in the formation, expression and
extinction phases of conditioned cued fear memories. Yet, despite a strong
clinical interest, a detailed understanding of these memory phases for contextual
fear memories is still missing. Besides the well-known role of the hippocampus in
encoding contextual fear behavior, growing evidence indicates that specific
regions of the medial prefrontal cortex differentially regulate contextual fear
acquisition and storage in both animals and humans that ultimately leads to
expression of contextual fear memories. In this review, we provide a detailed
description of the recent literature on the role of distinct prefrontal
subregions in contextual fear behavior and provide a working model of the
neuronal circuits involved in the acquisition, expression and generalization of
contextual fear memories.
© 2014 John Wiley & Sons Ltd and International Behavioural and Neural Genetics
Society.
DOI: 10.1111/gbb.12181
PMID: 25287656 [Indexed for MEDLINE]