Neuronal Circuits for Fear Expression and Recovery: Recent Advances and Potential Therapeutic Strategies
Biol Psychiatry. 2015-09-01; 78(5): 298-306
DOI: 10.1016/j.biopsych.2015.03.017
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1. Biol Psychiatry. 2015 Sep 1;78(5):298-306. doi: 10.1016/j.biopsych.2015.03.017.
Epub 2015 Mar 24.
Neuronal Circuits for Fear Expression and Recovery: Recent Advances and Potential
Therapeutic Strategies.
Dejean C(1), Courtin J(1), Rozeske RR(1), Bonnet MC(2), Dousset V(3), Michelet
T(4), Herry C(5).
Author information:
(1)Institut National de la Santé et de la Recherche Médicale U862, Neurocenter
Magendie, Physiopathologie de la Plasticité Neuronale, Bordeaux, France.
(2)Institut National de la Santé et de la Recherche Médicale U862, Neurocenter
Magendie, Physiopathologie de la Plasticité Neuronale, Bordeaux, France.;
Universitaire de Bordeaux, Institut de Bio-imagerie de Bordeaux, Bordeaux,
France.
(3)Institut National de la Santé et de la Recherche Médicale U862, Neurocenter
Magendie, Physiopathologie de la Plasticité Neuronale, Bordeaux, France.;
Universitaire de Bordeaux, Institut de Bio-imagerie de Bordeaux, Bordeaux,
France.; Centre Hospitalier Universitaire de Bordeaux, Service de NeuroImagerie
Diagnostique et Thérapeutique, Bordeaux, France.
(4)Unite Mixte de Recherche Centre National de la Recherche Scientifique 5293,
Institut des maladies Neurodégénératives, Bordeaux, France.
(5)Institut National de la Santé et de la Recherche Médicale U862, Neurocenter
Magendie, Physiopathologie de la Plasticité Neuronale, Bordeaux, France..
Electronic address: .
Recent technological developments, such as single unit recordings coupled to
optogenetic approaches, have provided unprecedented knowledge about the precise
neuronal circuits contributing to the expression and recovery of conditioned fear
behavior. These data have provided an understanding of the contributions of
distinct brain regions such as the amygdala, prefrontal cortex, hippocampus, and
periaqueductal gray matter to the control of conditioned fear behavior. Notably,
the precise manipulation and identification of specific cell types by optogenetic
techniques have provided novel avenues to establish causal links between changes
in neuronal activity that develop in dedicated neuronal structures and the short
and long-lasting expression of conditioned fear memories. In this review, we
provide an update on the key neuronal circuits and cell types mediating
conditioned fear expression and recovery and how these new discoveries might
refine therapeutic approaches for psychiatric conditions such as anxiety
disorders and posttraumatic stress disorder.
Copyright © 2015 Society of Biological Psychiatry. Published by Elsevier Inc. All
rights reserved.
DOI: 10.1016/j.biopsych.2015.03.017
PMID: 25908496 [Indexed for MEDLINE]