Modulation of brain PUFA content in different experimental models of mice

Corinne Joffre, Stéphane Grégoire, Véronique De Smedt, Niyazi Acar, Lionel Bretillon, Agnès Nadjar, Sophie Layé
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2016-11-01; 114: 1-10
DOI: 10.1016/j.plefa.2016.09.003

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The relative amounts of arachidonic acid (AA) and docosahexaenoic acid (DHA)
govern the different functions of the brain. Their brain levels depend on
structures considered, on fatty acid dietary supply and the age of animals. To
have a better overview of the different models available in the literature we
here compared the brain fatty acid composition in various mice models (C57BL/6J,
CD1, Fat-1, SAMP8 mice) fed with different n-3 PUFA diets (deficient, balanced,
enriched) in adults and aged animals. Our results demonstrated that brain AA and
DHA content is 1) structure-dependent; 2) strain-specific; 3) differently
affected by dietary approaches when compared to genetic model of PUFA modulation;
4) different in n-3 PUFA deficient aged C57BL6/J when compared to SAMP8 mouse
model of aging. From these experiments, we highlight the difficulty to compare
results obtained in different mouse models, different strains, different brain
regions and different ages.

Published by Elsevier Ltd.


Auteurs Bordeaux Neurocampus