Microglial Activation Enhances Associative Taste Memory through Purinergic Modulation of Glutamatergic Neurotransmission

J.-C. Delpech, N. Saucisse, S. L. Parkes, C. Lacabanne, A. Aubert, F. Casenave, E. Coutureau, N. Sans, S. Laye, G. Ferreira, A. Nadjar
Journal of Neuroscience. 2015-02-18; 35(7): 3022-3033
DOI: 10.1523/jneurosci.3028-14.2015

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Delpech JC(1), Saucisse N(1), Parkes SL(2), Lacabanne C(1), Aubert A(1), Casenave F(1), Coutureau E(3), Sans N(4), Layé S(1), Ferreira G(5), Nadjar A(5).

Author information:
(1)INRA, Nutrition et Neurobiologie intégrée, Unité Mixte de Recherche 1286,
Bordeaux, France, University of Bordeaux, Nutrition et Neurobiologie intégrée,
Unité Mixte de Recherche 1286, Bordeaux, France.
(2)INRA, Nutrition et Neurobiologie intégrée, Unité Mixte de Recherche 1286,
Bordeaux, France, University of Bordeaux, Nutrition et Neurobiologie intégrée,
Unité Mixte de Recherche 1286, Bordeaux, France, Centre National de la Recherche
Scientifique, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine,
Unité Mixte de Recherche 5287, 33076 Bordeaux, France, Université de Bordeaux,
Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, 33076 Bordeaux,
France.
(3)Centre National de la Recherche Scientifique, Institut de Neurosciences
Cognitives et Intégratives d’Aquitaine, Unité Mixte de Recherche 5287, 33076
Bordeaux, France, Université de Bordeaux, Institut de Neurosciences Cognitives et
Intégratives d’Aquitaine, 33076 Bordeaux, France.
(4)Institut National de la Santé et de la Recherche Médicale, U862 NeuroCentre
Magendie, Planar Polarity and Plasticity Group, Bordeaux, France, and University
of Bordeaux, U862 NeuroCentre Magendie, Bordeaux, France.
(5)INRA, Nutrition et Neurobiologie intégrée, Unité Mixte de Recherche 1286,
Bordeaux, France, University of Bordeaux, Nutrition et Neurobiologie intégrée,
Unité Mixte de Recherche 1286, Bordeaux, France,
.

The cerebral innate immune system is able to modulate brain functioning and
cognitive processes. During activation of the cerebral innate immune system,
inflammatory factors produced by microglia, such as cytokines and adenosine
triphosphate (ATP), have been directly linked to modulation of glutamatergic
system on one hand and learning and memory functions on the other hand. However,
the cellular mechanisms by which microglial activation modulates cognitive
processes are still unclear. Here, we used taste memory tasks, highly dependent
on glutamatergic transmission in the insular cortex, to investigate the
behavioral and cellular impacts of an inflammation restricted to this cortical
area in rats. We first show that intrainsular infusion of the endotoxin
lipopolysaccharide induces a local inflammation and increases glutamatergic AMPA,
but not NMDA, receptor expression at the synaptic level. This cortical
inflammation also enhances associative, but not incidental, taste memory through
increase of glutamatergic AMPA receptor trafficking. Moreover, we demonstrate
that ATP, but not proinflammatory cytokines, is responsible for
inflammation-induced enhancement of both associative taste memory and AMPA
receptor expression in insular cortex. In conclusion, we propose that
inflammation restricted to the insular cortex enhances associative taste memory
through a purinergic-dependent increase of glutamatergic AMPA receptor expression
at the synapse.

Copyright © 2015 the authors 0270-6474/15/353022-12$15.00/0.

DOI: 10.1523/JNEUROSCI.3028-14.2015
PMID: 25698740 [Indexed for MEDLINE]


Auteurs Bordeaux Neurocampus