Genetic dissection of variation in hippocampal intra-and infrapyramidal mossy fibers in the mouse

Anna Delprato, Wim E. Crusio
Methods in Molecular Biology. 2016-12-09; : 419-430
DOI: 10.1007/978-1-4939-6427-7_19

PubMed
Lire sur PubMed



1. Methods Mol Biol. 2017;1488:419-430.

Genetic Dissection of Variation in Hippocampal Intra- and Infrapyramidal Mossy
Fibers in the Mouse.

Delprato A(1)(2)(3), Crusio WE(4)(5)(6).

Author information:
(1)Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, UMR 5287,
University of Bordeaux, Bat B2 – Allée Geoffroy St. Hilaire, CS 50023, Pessac,
France. *protected email*.
(2)CNRS, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, UMR
5287, Pessac, France. *protected email*.
(3)BioScience Project, 3266, Wakefield, MA, 01880, USA.
*protected email*.
(4)Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, UMR 5287,
University of Bordeaux, Bat B2 – Allée Geoffroy St. Hilaire, CS 50023, Pessac,
France.
(5)CNRS, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, UMR
5287, Pessac, France.
(6)BioScience Project, 3266, Wakefield, MA, 01880, USA.

This chapter describes the genetic analysis of a morphometric neuroanatomic
trait. We used the extended BXD family of recombinant inbred mouse strains with
the intent to analyze the genetic bases of heritable differences in hippocampal
neurocircuitry and to identify Quantitative Trait Loci that underlie these
variations. A detailed description of a GeneNetwork analysis is provided using
data for the intra- and infrapyramidal mossy fiber (IIPMF) terminal fields which
are strongly correlated with spatial navigation/radial maze learning.

DOI: 10.1007/978-1-4939-6427-7_19
PMID: 27933536 [Indexed for MEDLINE]


Auteurs Bordeaux Neurocampus