Genetic Dissection of Variation in Hippocampal Intra- and Infrapyramidal Mossy Fibers in the Mouse

Methods Mol Biol. 2017:1488:419-430. doi: 10.1007/978-1-4939-6427-7_19.

Abstract

This chapter describes the genetic analysis of a morphometric neuroanatomic trait. We used the extended BXD family of recombinant inbred mouse strains with the intent to analyze the genetic bases of heritable differences in hippocampal neurocircuitry and to identify Quantitative Trait Loci that underlie these variations. A detailed description of a GeneNetwork analysis is provided using data for the intra- and infrapyramidal mossy fiber (IIPMF) terminal fields which are strongly correlated with spatial navigation/radial maze learning.

Keywords: Complex traits; Hippocampal morphometry; Intra- and infrapyramidal mossy fibers; Quantitative trait loci; Recombinant inbred mice; Systems genetics.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Biomarkers
  • Chromosome Mapping
  • Computational Biology / methods
  • Epistasis, Genetic
  • Female
  • Gene Expression Regulation
  • Gene Regulatory Networks
  • Genetic Association Studies*
  • Genetic Variation*
  • Male
  • Mice
  • Mice, Inbred Strains
  • Mossy Fibers, Hippocampal / metabolism*
  • Quantitative Trait Loci
  • Quantitative Trait, Heritable
  • Recombination, Genetic
  • Software

Substances

  • Biomarkers