Expression analysis of neuroleukin, calmodulin, cortactin, and Rho7/Rnd2 in the intact and injured mouse brain.
Developmental Brain Research. 2005-09-01; 159(1): 36-54
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1. Brain Res Dev Brain Res. 2005 Sep 8;159(1):36-54.
Expression analysis of neuroleukin, calmodulin, cortactin, and Rho7/Rnd2 in the
intact and injured mouse brain.
Decourt B(1), Bouleau Y, Dulon D, Hafidi A.
(1)EA3665, Laboratoire de Biologie Cellulaire et Moléculaire de l’Audition,
Université Victor Segalen Bordeaux 2, Hôpital Pellegrin, Bâtiment PQR 3, 33076
Subtracted cDNA libraries from the mouse developing inferior colliculus were
previously constructed between postnatal day (P) 6 and 10. In the P10-P6
subtracted library, neuroleukin, calmodulin I, cortactin, and Rho7 were
identified. The goal of the present study was to analyze their distribution, at
the mRNA and protein levels, in both the adult and the developing mouse brain.
The four molecules showed a wide expression throughout the brain, with a
neuronal-enriched localization in structures such as the cortex, the hippocampus,
the cerebellum, and the inferior colliculus. The level of expression of their
corresponding mRNAs increased during brain postnatal development. The expression
of these molecules was also investigated 2 weeks after a mechanical lesion in the
adult cerebral cortex. Neuroleukin and cortactin were found to be expressed by
reactive astrocytes, while there were no changes in the expression of calmodulin
and Rho7. The expression of neuroleukin, calmodulin, cortactin, and Rho7 is
discussed in the context of their putative role in the maturation of the brain
and in the axonal regeneration process.
PMID: 16051374 [Indexed for MEDLINE]