Didier Dulon

Publications

• Hyperacusis in the Adult Fmr1-KO Mouse Model of Fragile X Syndrome: The Therapeutic Relevance of Cochlear Alterations and BKCa Channels
  Celeste Ferraguto, Yohan Bouleau, Thibault Peineau, Didier Dulon, Susanna Pietropaolo.
  IJMS. 2023-07-24. 24(14) : 11863.
  10.3390/ijms241411863
• Otoferlin as a multirole Ca2+ signaling protein: from inner ear synapses to cancer pathways
  Jean-Christophe Leclère, Didier Dulon.
  Front. Cell. Neurosci.. 2023-07-19. 17
  10.3389/fncel.2023.1197611
• The SNARE protein SNAP-25 is required for normal exocytosis at auditory hair cell ribbon synapses.
  Charlotte Calvet, Thibault Peineau, Najate Benamer, Maxence Cornille, Andrea Lelli, Baptiste Plion, Ghizlène Lahlou, Julia Fanchette, Sylvie Nouaille, Jacques Boutet de Monvel, Amrit Estivalet, Philippe Jean, Vincent Michel, Martin Sachse, Nicolas Michalski, Paul Avan, Christine Petit, Didier Dulon, Saaid Safieddine.
  iScience. 2022-12-01. 25(12) : 105628.
  10.1016/j.isci.2022.105628
• Clarin‐2 is essential for hearing by maintaining stereocilia integrity and function
  Lucy A Dunbar, Pranav Patni, Carlos Aguilar, Philomena Mburu, Laura Corns, Helena RR Wells, Sedigheh Delmaghani, Andrew Parker, Stuart Johnson, Debbie Williams, Christopher T Esapa, Michelle M Simon, Lauren Chessum, Sherylanne Newton, Joanne Dorning, Prashanthini Jeyarajan, Susan Morse, Andrea Lelli, Gemma F Codner, Thibault Peineau, Suhasini R Gopal, Kumar N Alagramam, Ronna Hertzano, Didier Dulon, Sara Wells, Frances M Williams, Christine Petit, Sally J Dawson, Steve DM Brown, Walter Marcotti, Aziz El‐Amraoui, Michael R Bowl.
  EMBO Mol Med. 2019-08-26. 11(9)
  10.15252/emmm.201910288
• Viral Transfer of Mini-Otoferlins Partially Restores the Fast Component of Exocytosis and Uncovers Ultrafast Endocytosis in Auditory Hair Cells of Otoferlin Knock-Out Mice.
  Margot Tertrais, Yohan Bouleau, Alice Emptoz, Séverin Belleudy, R Bryan Sutton, Christine Petit, Saaid Safieddine, Didier Dulon.
  J. Neurosci.. 2019-03-04. : 1550-18.
  10.1523/jneurosci.1550-18.2018
• Clustered Ca2+ Channels Are Blocked by Synaptic Vesicle Proton Release at Mammalian Auditory Ribbon Synapses
  Philippe F.Y. Vincent, Soyoun Cho, Margot Tertrais, Yohan Bouleau, Henrique von Gersdorff, Didier Dulon.
  Cell Reports. 2018-12-01. 25(12) : 3451-3464.e3.
  10.1016/j.celrep.2018.11.072
• Clarin-1 gene transfer rescues auditory synaptopathy in model of Usher syndrome
  Didier Dulon, Samantha Papal, Pranav Patni, Matteo Cortese, Philippe F.Y. Vincent, Margot Tertrais, Alice Emptoz, Abdelaziz Tlili, Yohan Bouleau, Vincent Michel, Sedigheh Delmaghani, Alain Aghaie, Elise Pepermans, Olinda Alegria-Prevot, Omar Akil, Lawrence Lustig, Paul Avan, Saaid Safieddine, Christine Petit, Aziz El-Amraoui.
  Journal of Clinical Investigation. 2018-07-09. 128(8) : 3382-3401.
  10.1172/jci94351
• Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses.
  Nicolas Michalski, Juan D Goutman, Sarah Marie Auclair, Jacques Boutet de Monvel, Margot Tertrais, Alice Emptoz, Alexandre Parrin, Sylvie Nouaille, Marc Guillon, Martin Sachse, Danica Ciric, Amel Bahloul, Jean-Pierre Hardelin, Roger Bryan Sutton, Paul Avan, Shyam S Krishnakumar, James E Rothman, Didier Dulon, Saaid Safieddine, Christine Petit.
  eLife. 2017-11-07. 6
  10.7554/elife.31013
• Local gene therapy durably restores vestibular function in a mouse model of Usher syndrome type 1G.
  Alice Emptoz, Vincent Michel, Andrea Lelli, Omar Akil, Jacques Boutet de Monvel, Ghizlene Lahlou, Anaïs Meyer, Typhaine Dupont, Sylvie Nouaille, Elody Ey, Filipa Franca de Barros, Mathieu Beraneck, Didier Dulon, Jean-Pierre Hardelin, Lawrence Lustig, Paul Avan, Christine Petit, Saaid Safieddine.
  Proc Natl Acad Sci USA. 2017-08-23. 114(36) : 9695-9700.
  10.1073/pnas.1708894114
• Different CaV1.3 Channel Isoforms Control Distinct Components of the Synaptic Vesicle Cycle in Auditory Inner Hair Cells.
  Philippe F.Y. Vincent, Yohan Bouleau, Gilles Charpentier, Alice Emptoz, Saaid Safieddine, Christine Petit, Didier Dulon.
  J. Neurosci.. 2017-02-13. 37(11) : 2960-2975.
  10.1523/jneurosci.2374-16.2017
• Increasing intracellular free calcium induces circumferential contractions in isolated cochlear outer hair cells.
  1388-97.
  J Neurosci.. 1990-04-15. (10) : 4.
  
• Actions of subtype-specific purinergic ligands on rat spiral ganglion neurons.
  Ito K, Iwasaki S, Kondo K, Dulon D, Kaga K..
  Acta Otolaryngol Suppl.. 2004-08. (553) : 23-7.
  
• Motility of cochlear outer hair cells.
  .
  Am J Otol.. 1992-03-01. 13(2) : 108-12.
  
• A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells.
  Philippe FY Vincent, Yohan Bouleau, Christine Petit, Didier Dulon.
  eLife. 2015-11-14. 4
  10.7554/elife.10988
• Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes.
  Sedigheh Delmaghani, Jean Defourny, Asadollah Aghaie, Maryline Beurg, Didier Dulon, Nicolas Thelen, Isabelle Perfettini, Tibor Zelles, Mate Aller, Anaïs Meyer, Alice Emptoz, Fabrice Giraudet, Michel Leibovici, Sylvie Dartevelle, Guillaume Soubigou, Marc Thiry, E. Sylvester Vizi, Saaid Safieddine, Jean-Pierre Hardelin, Paul Avan, Christine Petit.
  Cell. 2015-11-01. 163(4) : 894-906.
  10.1016/j.cell.2015.10.023
• Exocytotic machineries of vestibular type I and cochlear ribbon synapses display similar intrinsic otoferlin-dependent Ca2+ sensitivity but a different coupling to Ca2+ channels.
  P. F. Y. Vincent, Y. Bouleau, S. Safieddine, C. Petit, D. Dulon.
  Journal of Neuroscience. 2014-08-13. 34(33) : 10853-10869.
  10.1523/jneurosci.0947-14.2014
• The temporal characteristics of Ca2+ entry through L-type and T-type Ca2+ channels shape exocytosis efficiency in chick auditory hair cells during development.
  Snezana Levic, Didier Dulon.
  Journal of Neurophysiology. 2012-12-01. 108(11) : 3116-3123.
  10.1152/jn.00555.2012
• Regulation of POU4F3 gene expression in hair cells by 5′ DNA in mice.
  M. Masuda, D. Dulon, K. Pak, L.M. Mullen, Y. Li, L. Erkman, A.F. Ryan.
  Neuroscience. 2011-12-01. 197 : 48-64.
  10.1016/j.neuroscience.2011.09.033
• Developmental acquisition of a rapid calcium-regulated vesicle supply allows sustained high rates of exocytosis in auditory hair cells.
  Snezana Levic, Yohan Bouleau, Didier Dulon.
  PLoS ONE. 2011-10-06. 6(10) : e25714.
  10.1371/journal.pone.0025714
• Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells.
  M. Beurg, N. Michalski, S. Safieddine, Y. Bouleau, R. Schneggenburger, E. R. Chapman, C. Petit, D. Dulon.
  Journal of Neuroscience. 2010-10-06. 30(40) : 13281-13290.
  10.1523/jneurosci.2528-10.2010
• Purinergic signaling in cochleovestibular hair cells and afferent neurons.
  Ken Ito, Didier Dulon.
  Purinergic Signalling. 2010-05-20. 6(2) : 201-209.
  10.1007/s11302-010-9183-x
• Otoferlin is critical for a highly sensitive and linear calcium-dependent exocytosis at vestibular hair cell ribbon synapses.
  D. Dulon, S. Safieddine, S. M. Jones, C. Petit.
  Journal of Neuroscience. 2009-08-26. 29(34) : 10474-10487.
  10.1523/jneurosci.1009-09.2009
• Is otospiralin inner ear specific? Evidence for its expression in mouse brain.
  Boris Decourt, Dean Hillman, Yohan Bouleau, Didier Dulon, Aziz Hafidi.
  International Journal of Developmental Neuroscience. 2009-02-01. 27(1) : 87-96.
  10.1016/j.ijdevneu.2008.09.001
• Expression of Rho GTPases Rho-A and Rac1 in the adult and developing gerbil cerebellum.
  Vaea Richard, Didier Dulon, Aziz Hafidi.
  International Journal of Developmental Neuroscience. 2008-11-01. 26(7) : 723-732.
  10.1016/j.ijdevneu.2008.07.010
• Calcium- and otoferlin-dependent exocytosis by immature outer hair cells.
  M. Beurg, S. Safieddine, I. Roux, Y. Bouleau, C. Petit, D. Dulon.
  Journal of Neuroscience. 2008-02-20. 28(8) : 1798-1803.
  10.1523/jneurosci.4653-07.2008
• Zinc protection against pneumolysin toxicity on rat cochlear hair cells.
  Valérie Franco-Vidal, Maryline Beurg, Vincent Darrouzet, Jean-Pierre Bébéar, Liam J. Skinner, Didier Dulon.
  Audiol Neurotol. 2007-09-21. 13(1) : 65-70.
  10.1159/000108763
• Multifrequency immittancemetry in experimentally induced stapes, round window and cochlear lesions.
  Vincent Darrouzet, Didier Dulon, Valérie Franco-Vidal.
  Audiol Neurotol. 2007-01-01. 12(2) : 85-100.
  10.1159/000097795
• Neuromodulation in the spiral ganglion: shaping signals from the organ of corti to the CNS.
  D. Dulon, D.J. Jagger, X. Lin, R.L. Davis.
  J Membrane Biol. 2006-01-01. 209(2-3) : 167-175.
  10.1007/s00232-005-0841-9
• The mechanism of pneumolysin-induced cochlear hair cell death in the rat.
  Maryline Beurg, Aziz Hafidi, Liam Skinner, Graeme Cowan, Yannick Hondarrague, Tim J. Mitchell, Didier Dulon.
  The Journal of Physiology. 2005-09-28. 568(1) : 211-227.
  10.1113/jphysiol.2005.092478
• Expression analysis of neuroleukin, calmodulin, cortactin, and Rho7/Rnd2 in the intact and injured mouse brain.
  Boris Decourt, Yohan Bouleau, Didier Dulon, Aziz Hafidi.
  Developmental Brain Research. 2005-09-01. 159(1) : 36-54.
  10.1016/j.devbrainres.2005.06.013
• Identification of differentially expressed genes in the developing mouse inferior colliculus.
  Boris Decourt, Yohan Bouleau, Didier Dulon, Aziz Hafidi.
  Developmental Brain Research. 2005-09-01. 159(1) : 29-35.
  10.1016/j.devbrainres.2005.06.010
• Ryanodine receptors and BK channels act as a presynaptic depressor of neurotransmission in cochlear inner hair cells.
  Maryline Beurg, Aziz Hafidi, Liam J. Skinner, Jérome Ruel, Régis Nouvian, Morgana Henaff, Jean-Luc Puel, Jean-Marie Aran, Didier Dulon.
  European Journal of Neuroscience. 2005-09-01. 22(5) : 1109-1119.
  10.1111/j.1460-9568.2005.04310.x
• Localization and developmental expression of BK channels in mammalian cochlear hair cells.
  A. Hafidi, M. Beurg, D. Dulon.
  Neuroscience. 2005-01-01. 130(2) : 475-484.
  10.1016/j.neuroscience.2004.09.038
• Intracochlear perfusion of pneumolysin, a pneumococcal protein, rapidly abolishes auditory potentials in the Guinea pig cochlea.
  Liam J. Skinner, Maryline Beurg, Timothy J. Mitchell, Vincent Darrouzet, Jean-marie Aran, Didier Dulon.
  Acta Oto-Laryngologica. 2004-11-01. 124(9) : 1000-1007.
  10.1080/00016480410017125
• Developmental expression of Ca(v)1.3 (alpha1d) calcium channels in the mouse inner ear.
  A Hafidi, D Dulon.
  Developmental Brain Research. 2004-06-01. 150(2) : 167-175.
  10.1016/j.devbrainres.2004.03.007
• Effects of exposure of the ear to GSM microwaves: in vivo and in vitro experimental studies.
  Jean-Marie Aran, Nathalie Carrere, Yan Chalan, Pierre-Emmanuel Dulou, Sophie Larrieu, Luc Letenneur, Bernard Veyret, Didier Dulon.
  International Journal of Audiology. 2004-01-01. 43(9) : 545-554.
  10.1080/14992020400050069
• Effects of exposure of the ear to GSM microwaves: in vivo and in vitro experimental studies.
  Jean-Marie Aran, Nathalie Carrere, Yan Chalan, Pierre-Emmanuel Dulou, Sophie Larrieu, Luc Letenneur, Bernard Veyret, Didier Dulon.
  International Journal of Audiology. 2004-01-01. 43(9) : 545-554.
  10.1080/14992020400050069
• Contribution of BK Ca2+-activated K+ channels to auditory neurotransmission in the Guinea pig cochlea.
  Liam J. Skinner, Véronique Enée, Maryline Beurg, Hak Hyun Jung, Allen F. Ryan, Aziz Hafidi, Jean-Marie Aran, Didier Dulon.
  Journal of Neurophysiology. 2003-07-01. 90(1) : 320-332.
  10.1152/jn.01155.2002
• Substance P mobilizes intracellular calcium and activates a nonselective cation conductance in rat spiral ganglion neurons.
  Ken Ito, Claire Rome, Yohan Bouleau, Didier Dulon.
  European Journal of Neuroscience. 2002-12-01. 16(11) : 2095-2102.
  10.1046/j.1460-9568.2002.02292.x
• Comparative distribution of NK1, NK2, and NK3 receptors in the rat brainstem auditory nuclei.
  Aziz Hafidi, Maryline Beurg, Yohan Bouleau, Didier Dulon.
  Brain Research. 2002-08-01. 947(2) : 299-306.
  10.1016/s0006-8993(02)03139-6
• Comparative distribution of NK1, NK2, and NK3 receptors in the rat brainstem auditory nuclei.
  Aziz Hafidi, Maryline Beurg, Yohan Bouleau, Didier Dulon.
  Brain Research. 2002-08-01. 947(2) : 299-306.
  10.1016/s0006-8993(02)03139-6
• Nonselective cation conductance activated by muscarinic and purinergic receptors in rat spiral ganglion neurons.
  Ken Ito, Didier Dulon.
  American Journal of Physiology-Cell Physiology. 2002-05-01. 282(5) : C1121-C1135.
  10.1152/ajpcell.00364.2001
• The voltage-sensitive motor protein and the Ca2+-sensitive cytoskeleton in developing rat cochlear outer hair cells.
  Maryline Beurg, Yohan Bouleau, Didier Dulon.
  European Journal of Neuroscience. 2001-12-01. 14(12) : 1947-1952.
  10.1046/j.0953-816x.2001.01826.x
• Tetraethylammonium ions block the nicotinic cholinergic receptors of cochlear outer hair cells.
  Christophe Blanchet, Didier Dulon.
  Brain Research. 2001-10-01. 915(1) : 11-17.
  10.1016/s0006-8993(01)02806-2
• Gentamicin blocks ACh-evoked K+ current in guinea-pig outer hair cells by impairing Ca2+ entry at the cholinergic receptor.
  Christophe Blanchet, Carlos Eróstegui, Masashi Sugasawa, Didier Dulon.
  The Journal of Physiology. 2000-06-01. 525(3) : 641-654.
  10.1111/j.1469-7793.2000.t01-1-00641.x
• Acute and chronic effects of aminoglycosides on cochlear hair cells.
  Aran JM, Erre JP, Lima da Costa D, Debbarh I, Dulon D..
  Annals of the New York Academy of Sciences. 1999-11-01. 884(1) : 60-68.
  10.1111/j.1749-6632.1999.tb08636.x
• Muscarinic receptor-mediated calcium signaling in spiral ganglion neurons of the mammalian cochlea.
  Claire Rome, Defeng Luo, Didier Dulon.
  Brain Research. 1999-11-01. 846(2) : 196-203.
  10.1016/s0006-8993(99)02034-x
• The bacterial Neo gene confers neomycin resistance to mammalian cochlear hair cells.
  Didier Dulon, Allen F. Ryan.
  NeuroReport. 1999-04-01. 10(6) : 1189-1193.
  10.1097/00001756-199904260-00006
• Expression of small-conductance calcium-activated potassium channels (SK) in outer hair cells of the rat cochlea.
  Didier Dulon, Lin Luo, Chunyan Zhang, Allen F. Ryan.
  European Journal of Neuroscience. 1998-03-01. 10(3) : 907-915.
  10.1046/j.1460-9568.1998.00098.x
• Cholinergic responses in developing outer hair cells of the rat cochlea.
  Didier Dulon, Marc Lenoir.
  European Journal of Neuroscience. 1996-09-01. 8(9) : 1945-1952.
  10.1111/j.1460-9568.1996.tb01338.x
• ATP activates non-selective cation channels and calcium release in inner hair cells of the guinea-pig cochlea.
  M Sugasawa, C Erostegui, C Blanchet, D Dulon.
  The Journal of Physiology. 1996-03-15. 491(3) : 707-718.
  10.1113/jphysiol.1996.sp021251
• Direct measurements of Ca(2+)-activated K+ currents in inner hair cells of the guinea-pig cochlea using photolabile Ca2+ chelators.
  Didier Dulon, Masashi Sugasawa, Christophe Blanchet, Carlos Erostegui.
  Pflügers Arch. 1995-07-01. 430(3) : 365-373.
  10.1007/bf00373911
• Organic material concentration in auditory outer hair cells measured by laser interferometry.
  E. Laffon, D. Dulon, C. Aurousseau, S. Dilhaire, W. Claeys.
  Cytometry. 1995-05-01. 20(1) : 1-6.
  10.1002/cyto.990200102
• Uptake of amikacin by hair cells of the guinea pig cochlea and vestibule and ototoxicity: comparison with gentamicin.
  Jean-Marie Aran, Catherine Chappert, Didier Dulon, Jean-Paul Erre, Catherine Aurousseau.
  Hearing Research. 1995-02-01. 82(2) : 179-183.
  10.1016/0378-5955(94)00175-p
• Photo-released intracellular Ca2+ evokes reversible mechanical responses in supporting cells of the guinea-pig organ of Corti.
  D. Dulon, C. Blanchet, E. Laffon.
  Biochemical and Biophysical Research Communications. 1994-06-01. 201(3) : 1263-1269.
  10.1006/bbrc.1994.1841
• Mammalian cochlear outer hair cells density evaluated by means of an optical tweezer.
  E. Laffon, D. Dulon, B. Pouligny, C. Blanchet, J.M. Aran.
  Biochemical and Biophysical Research Communications. 1993-10-01. 196(1) : 363-368.
  10.1006/bbrc.1993.2257
• Characterization of Ca2+ signals generated by extracellular nucleotides in supporting cells of the organ of Corti.
  D Dulon, R Moataz, P Mollard.
  Cell Calcium. 1993-03-01. 14(3) : 245-254.
  10.1016/0143-4160(93)90071-d
• Cellular and subcellular localization of tritiated gentamicin in the guinea pig cochlea following combined treatment with ethacrynic acid.
  Hakim Hiel, Abdenbi Schamel, Jean-paul Erre, Tetsuro Hayashida, Didier Dulon, Jean-Marie Aran.
  Hearing Research. 1992-01-01. 57(2) : 157-165.
  10.1016/0378-5955(92)90148-g
• First appearance and development of motile properties in outer hair cells isolated from guinea-pig cochlea.
  Rémy Pujol, Gary Zajic, Didier Dulon, Yoash Raphael, Richard A. Altschuler, Jochen Schacht.
  Hearing Research. 1991-12-01. 57(1) : 129-141.
  10.1016/0378-5955(91)90082-k
• Cisplatin blocks depolarization-induced calcium entry in isolated cochlear outer hair cells.
  Takehisa Saito, Rachida Moataz, Didier Dulon.
  Hearing Research. 1991-11-01. 56(1-2) : 143-147.
  10.1016/0378-5955(91)90163-4
• Differential motile response of isolated inner and outer hair cells to stimulation by potassium and calcium ions.
  D. Dulon, G. Zajic, J. Schacht.
  Hearing Research. 1991-03-01. 52(1) : 225-231.
  10.1016/0378-5955(91)90202-k
• Aminoglycoside antibiotics impair calcium entry but not viability and motility in isolated cochlear outer hair cells.
  D. Dulon, G. Zajic, J.-M. Aran, J. Schacht.
  J. Neurosci. Res.. 1989-10-01. 24(2) : 338-346.
  10.1002/jnr.490240226
• Vestibular hair cells isolated from guinea pig labyrinth.
  Jean Valat, Gina Devau, Didier Dulon, Alain Sans.
  Hearing Research. 1989-07-01. 40(3) : 255-260.
  10.1016/0378-5955(89)90166-4
• Dynamic changes following combined treatment with gentamicin and ethacrynic acid with and without acoustic stimulation. Cellular uptake and functional correlates.
  Tetsuro Hayashida, Hakim Hiel, Didier Dulon, Jean-Paul Erre, Anne Guilhaume, Jean-Marie Aran.
  Acta Oto-Laryngologica. 1989-01-01. 108(5-6) : 404-413.
  10.3109/00016488909125546
• Photo-induced irreversible shortening and swelling of isolated cochlear outer hair cells.
  D. Dulon, G. Zajic, J. Schacht.
  International Journal of Radiation Biology. 1989-01-01. 55(6) : 1007-1014.
  10.1080/09553008914551031
• Potassium-depolarization induces motility in isolated outer hair cells by an osmotic mechanism.
  Didier Dulon, Jean Marie Aran, Jochen Schacht.
  Hearing Research. 1988-02-01. 32(2-3) : 123-129.
  10.1016/0378-5955(88)90084-6
• Relationship between the nephrotoxicity and ototoxicity induced by gentamicin in the guinea pig.
  Didier Dulon, Catherine Aurousseau, Jean-Paul Erre, Jean-Marie Aran, D. Dulon.
  Acta Oto-Laryngologica. 1988-01-01. 106(3-4) : 219-225.
  10.3109/00016488809106429
• Osmotically induced motility of outer hair cells: implications for Menière’s disease.
  D. Dulon, J. -M. Aran, J. Schacht.
  Arch Otorhinolaryngol. 1987-07-01. 244(2) : 104-107.
  10.1007/bf00458558
• Comparative uptake of gentamicin, netilmicin, and amikacin in the guinea pig cochlea and vestibule.
  D Dulon, J M Aran, G Zajic, J Schacht.
  Antimicrobial Agents and Chemotherapy. 1986-07-01. 30(1) : 96-100.
  10.1128/aac.30.1.96
• Study of the electrokinetic properties of reconstituted sarcoplasmic reticulum vesicles.
  Daniel Brèthes, Didier Dulon, Georges Johannin, Bernard Arrio, Thaddée Gulik-Krzywicki, Jean Chevallier.
  Archives of Biochemistry and Biophysics. 1986-04-01. 246(1) : 355-365.
  10.1016/0003-9861(86)90480-7