Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey
Brain Research. 1998-03-01; 787(1): 157-160
DOI: 10.1016/S0006-8993(97)01563-1
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1. Brain Res. 1998 Mar 16;787(1):157-60. doi: 10.1016/s0006-8993(97)01563-1.
Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe)
and globus pallidus internalis (GPi) in the MPTP-treated monkey.
Boraud T(1), Bezard E, Guehl D, Bioulac B, Gross C.
Author information:
(1)Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen
Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France.
We studied the effects of L-DOPA on the firing patterns of pallidal neurons in
experimental parkinsonism. After a unilateral injection of MPTP, we observed a
decrease in the firing rate of GPe neurons, and a slight increase in their
bursting activity. In the GPi, there was a considerable augmentation of both
neuronal firing frequency and the number of bursting cells. During l-DOPA
treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing
frequency of GPi neurons, on the contrary, decreased even lower than the control
level. A slight reduction was observed in bursting activity. These unexpected
results would show that the normalizing effect of L-DOPA on GPi output is
limited.
Copyright 1998 Elsevier Science B.V.
DOI: 10.1016/s0006-8993(97)01563-1
PMID: 9518590 [Indexed for MEDLINE]