Ecdysone receptor homologs from mollusks, leeches and a polychaete worm
FEBS Letters. 2010-10-08; 584(21): 4458-4462
DOI: 10.1016/j.febslet.2010.10.004
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Laguerre M(1), Veenstra JA.
Author information:
(1)UMR 5248 CNRS, Institut Européen de Chimie et Biologie, Pessac, France.
The genomes of the mollusk Lottia gigantea, the leech Helobdella robusta and the
polychaete worm Capitella teleta each have a gene encoding an ecdysone receptor
homolog. Publicly available genomic and EST sequences also contain evidence for
ecdysone receptors in the seahare Aplysia californica, the bobtail squid Euprymna
scolopes and the medicinal leech Hirudo medicinalis. Three-dimensional models of
the ligand binding domains of these predicted ecdysone receptor homologs suggest
that each of them could potentially bind an ecdysone-related steroid. Thus,
ecdysone receptors are not limited to arthropods and nematodes.
Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.