Ecdysone receptor homologs from mollusks, leeches and a polychaete worm

FEBS Lett. 2010 Nov 5;584(21):4458-62. doi: 10.1016/j.febslet.2010.10.004. Epub 2010 Oct 8.

Abstract

The genomes of the mollusk Lottia gigantea, the leech Helobdella robusta and the polychaete worm Capitella teleta each have a gene encoding an ecdysone receptor homolog. Publicly available genomic and EST sequences also contain evidence for ecdysone receptors in the seahare Aplysia californica, the bobtail squid Euprymna scolopes and the medicinal leech Hirudo medicinalis. Three-dimensional models of the ligand binding domains of these predicted ecdysone receptor homologs suggest that each of them could potentially bind an ecdysone-related steroid. Thus, ecdysone receptors are not limited to arthropods and nematodes.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Computational Biology*
  • Humans
  • Leeches*
  • Models, Molecular
  • Molecular Sequence Data
  • Mollusca*
  • Phylogeny
  • Polychaeta*
  • Protein Structure, Tertiary
  • Receptors, Steroid / chemistry*
  • Receptors, Steroid / genetics
  • Receptors, Steroid / metabolism*
  • Sequence Alignment
  • Sequence Homology, Amino Acid*

Substances

  • Receptors, Steroid
  • ecdysone receptor