Adult hippocampal neurogenesis is involved in anxiety-related behaviors

J-M Revest, D Dupret, M Koehl, C Funk-Reiter, N Grosjean, P-V Piazza, D N Abrous
Mol Psychiatry. 2009-03-03; 14(10): 959-967
DOI: 10.1038/mp.2009.15

PubMed
Lire sur PubMed



Adult hippocampal neurogenesis is a unique example of structural plasticity, the functional role of which has been a matter of intense debate. New transgenic models have recently shown that neurogenesis participates in hippocampus-mediated
learning. Here, we show that transgenic animals, in which adult hippocampal neurogenesis has been specifically impaired, exhibit a striking increase in anxiety-related behaviors. Our results indicate that neurogenesis plays an important role in the regulation of affective states and could be the target of new treatments for anxiety disorders.


Auteurs Bordeaux Neurocampus