Abstract
Adult hippocampal neurogenesis is a unique example of structural plasticity, the functional role of which has been a matter of intense debate. New transgenic models have recently shown that neurogenesis participates in hippocampus-mediated learning. Here, we show that transgenic animals, in which adult hippocampal neurogenesis has been specifically impaired, exhibit a striking increase in anxiety-related behaviors. Our results indicate that neurogenesis plays an important role in the regulation of affective states and could be the target of new treatments for anxiety disorders.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anxiety / drug therapy
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Anxiety / physiopathology*
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Behavior, Animal / drug effects
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Behavior, Animal / physiology
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Cell Count
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Chlordiazepoxide / pharmacology
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Depression / physiopathology
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Doxycycline / pharmacology
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Hippocampus / drug effects
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Hippocampus / metabolism
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Hippocampus / physiology*
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Male
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Mice
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Mice, Inbred C57BL
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Mice, Transgenic
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Neurogenesis / drug effects
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Neurogenesis / genetics
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Neurogenesis / physiology*
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Neurons / cytology
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Neurons / drug effects
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Neurons / metabolism
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bcl-2-Associated X Protein / genetics
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bcl-2-Associated X Protein / metabolism
Substances
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bcl-2-Associated X Protein
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Chlordiazepoxide
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Doxycycline