
Xavier Fioramonti

Publications
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Blockage of ATGL-mediated breakdown of lipid droplets in microglia alleviates neuroinflammatory and behavioural responses to lipopolysaccharides.
Brain, Behavior, and Immunity. 2025-01-01. 123 : 315-333.
10.1016/j.bbi.2024.09.027 -
A neuronal circuit driven by GLP-1 in the olfactory bulb regulates insulin secretion
Nat Commun. 2024-08-13. 15(1)
10.1038/s41467-024-51076-4 -
Single cell tracing of Pomc neurons reveals recruitment of ‘Ghost’ subtypes with atypical identity in a mouse model of obesity
Nat Commun. 2024-04-24. 15(1)
10.1038/s41467-024-47877-2 -
Serotonergic neurons are involved in the counter-regulatory response to hypoglycemia.
J Neuroendocrinology. 2023-10-19.
10.1111/jne.13344 -
A New Role for Hypothalamic Glucose-Sensing Neurons in Hypoglycemia Unawareness
Diabetes. 2023-07-20. 72(8) : 1055-1056.
10.2337/dbi22-0038 -
Memory deficits in a juvenile rat model of type 1 diabetes are due to excess 11β-HSD1 activity, which is upregulated by high glucose concentrations rather than insulin deficiency
Diabetologia. 2023-06-10.
10.1007/s00125-023-05942-3 -
Insulin modulates emotional behavior through a serotonin-dependent mechanism
Mol Psychiatry. 2022-10-07.
10.1038/S41380-022-01812-3 -
Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain
Sci. Adv.. 2022-07-29. 8(30)
10.1126/sciadv.abo0689 -
Dietary Long-Chain n-3 Polyunsaturated Fatty Acid Supplementation Alters Electrophysiological Properties in the Nucleus Accumbens and Emotional Behavior in Naïve and Chronically Stressed Mice
IJMS. 2022-06-14. 23(12) : 6650.
10.3390/ijms23126650 -
The menace of obesity to depression and anxiety prevalence
Trends in Endocrinology & Metabolism. 2022-01-01. 33(1) : 18-35.
10.1016/j.tem.2021.10.005 -
Functional heterogeneity of POMC neurons relies on mTORC1 signaling
Cell Reports. 2021-10-01. 37(2) : 109800.
10.1016/j.celrep.2021.109800 -
The impact of insulin on the serotonergic system and consequences on diabetes‐associated mood disorders
J Neuroendocrinology. 2021-01-28. 33(4)
10.1111/jne.12928 -
Tetracosahexaenoylethanolamide, a novel n-acylethanolamide, is elevated in ischemia and increases neuronal output
J. Lipid Res.. 2020-08-21. : jlr.RA120001024.
10.1194/jlr.ra120001024 -
In silico Hierarchical Clustering of Neuronal Populations in the Rat Ventral Tegmental Area Based on Extracellular Electrophysiological Properties
Front. Neural Circuits. 2020-08-13. 14
10.3389/fncir.2020.00051 -
Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits.
Cell Metabolism. 2020-04-01. 31(4) : 755-772.e7.
10.1016/j.cmet.2020.02.012 -
Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons
Cell Metabolism. 2020-03-01.
10.1016/j.cmet.2020.02.010 -
POMC Neurons Dysfunction in Diet-induced Metabolic Disease: Hallmark or Mechanism of Disease?
Neuroscience. 2019-11-01.
10.1016/j.neuroscience.2019.09.031 -
Metformin promotes anxiolytic and antidepressant-like responses in insulin-resistant mice by decreasing circulating branched-chain amino acids
J. Neurosci.. 2019-06-03. 39(30) : 5935-5948.
10.1523/jneurosci.2904-18.2019 -
The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system
J Clin Invest. 2019-04-02.
10.1172/JCI123454 -
Editorial: Brain Nutrient Sensing in the Control of Energy Balance: New Insights and Perspectives
Front. Physiol.. 2019-02-05. 10
10.3389/fphys.2019.00051 -
Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing.
Molecular Metabolism. 2019-02-01. 20 : 166-177.
10.1016/j.molmet.2018.11.007 -
Recent Advances in the Cellular and Molecular Mechanisms of Hypothalamic Neuronal Glucose Detection
Front. Physiol.. 2017-11-14. 8
10.3389/fphys.2017.00875 -
Lipoprotein lipase in hypothalamus is a key regulator of body weight gain and glucose homeostasis in mice
Diabetologia. 2017-04-29. 60(7) : 1314-1324.
10.1007/s00125-017-4282-7 -
Transient Receptor Potential Canonical 3 (TRPC3) Channels Are Required for Hypothalamic Glucose Detection and Energy Homeostasis
Diabetes. 2016-11-29. 66(2) : 314-324.
10.2337/db16-1114 -
Hypothalamic sensing of ketone bodies after prolonged cerebral exposure leads to metabolic control dysregulation
Sci Rep. 2016-10-06. 6(1)
10.1038/srep34909 -
Central chronic apelin infusion decreases energy expenditure and thermogenesis in mice
Sci Rep. 2016-08-23. 6(1)
10.1038/srep31849 -
Glucose and hypothalamic astrocytes: More than a fueling role?
Neuroscience. 2016-05-01. 323 : 110-120.
10.1016/j.neuroscience.2015.06.007 -
Gut Commensal E. coli Proteins Activate Host Satiety Pathways following Nutrient-Induced Bacterial Growth
Cell Metabolism. 2016-02-01. 23(2) : 324-334.
10.1016/j.cmet.2015.10.017 -
Evidence for hypothalamic ketone body sensing: impact on food intake and peripheral metabolic responses in mice
American Journal of Physiology-Endocrinology and Metabolism. 2016-01-15. 310(2) : E103-E115.
10.1152/ajpendo.00282.2015 -
Attenuated Levels of Hippocampal Connexin 43 and its Phosphorylation Correlate with Antidepressant- and Anxiolytic-Like Activities in Mice
Front. Cell. Neurosci.. 2015-12-22. 9
10.3389/fncel.2015.00490 -
Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice
Molecular Metabolism. 2014-12-01. 3(9) : 848-854.
10.1016/j.molmet.2014.09.006 -
Hypothalamic astroglial connexins are required for brain glucose sensing-induced insulin secretion.
J Cereb Blood Flow Metab. 2013-12-04. 34(2) : 339-346.
10.1038/jcbfm.2013.206 -
Membrane potential dye imaging of ventromedial hypothalamus neurons from adult mice to study glucose sensing
JoVE. 2013-11-27. (81)
10.3791/50861 -
Hypothalamic S-nitrosylation contributes to the counter-regulatory response impairment following recurrent hypoglycemia
PLoS ONE. 2013-07-19. 8(7) : e68709.
10.1371/journal.pone.0068709 -
Soluble guanylyl cyclase is a target of angiotensin II-induced nitrosative stress in a hypertensive rat model
American Journal of Physiology-Heart and Circulatory Physiology. 2012-09-01. 303(5) : H597-H604.
10.1152/ajpheart.00138.2012 -
Food intake adaptation to dietary fat involves PSA-dependent rewiring of the arcuate melanocortin system in mice
J. Neurosci.. 2012-08-29. 32(35) : 11970-11979.
10.1523/jneurosci.0624-12.2012 -
Importance of mitochondrial dynamin-related protein 1 in hypothalamic glucose sensitivity in rats.
Antioxidants & Redox Signaling. 2012-08-01. 17(3) : 433-444.
10.1089/ars.2011.4254 -
NO resistance in angiotensin II–induced hypertension is associated with S-nitrosation of soluble guanylyl cyclase
BMC Pharmacol. 2011-08-01. 11(S1)
10.1186/1471-2210-11-S1-O33 -
Hypothalamic nitric oxide in hypoglycemia detection and counterregulation: a two-edged sword
Antioxidants & Redox Signaling. 2011-02-01. 14(3) : 505-517.
10.1089/ars.2010.3331 -
Ventromedial hypothalamic nitric oxide production is necessary for hypoglycemia detection and counterregulation
Diabetes. 2009-11-23. 59(2) : 519-528.
10.2337/db09-0421 -
Deregulation of hepatic insulin sensitivity induced by central lipid infusion in rats is mediated by nitric oxide
PLoS ONE. 2009-08-14. 4(8) : e6649.
10.1371/journal.pone.0006649 -
Fasting enhances the response of arcuate neuropeptide Y-glucose-inhibited neurons to decreased extracellular glucose
American Journal of Physiology-Cell Physiology. 2009-04-01. 296(4) : C746-C756.
10.1152/ajpcell.00641.2008 -
Nitroglycerin-induced S-nitrosylation and desensitization of soluble guanylyl cyclase contribute to nitrate tolerance
Circulation Research. 2008-09-12. 103(6) : 606-614.
10.1161/CIRCRESAHA.108.175133 -
Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice
Cell Metabolism. 2008-09-01. 8(3) : 201-211.
10.1016/j.cmet.2008.08.008 -
Insulin internalizes GLUT2 in the enterocytes of healthy but not insulin-resistant mice
Diabetes. 2008-03-01. 57(3) : 555-562.
10.2337/db07-0928 -
Characterization of glucosensing neuron subpopulations in the arcuate nucleus: integration in neuropeptide Y and pro-opio melanocortin networks?
Diabetes. 2007-05-01. 56(5) : 1219-1227.
10.2337/db06-0567 -
Role for mitochondrial reactive oxygen species in brain lipid sensing: redox regulation of food intake
Diabetes. 2007-01-01. 56(1) : 152-160.
10.2337/db06-0440 -
Brain glucose sensing: a subtle mechanism
Current Opinion in Clinical Nutrition & Metabolic Care. 2006-07-01. 9(4) : 458-462.
10.1097/01.mco.0000232908.84483.e0 -
A new ATP-sensitive K+ channel-independent mechanism is involved in glucose-excited neurons of mouse arcuate nucleus
Diabetes. 2004-10-25. 53(11) : 2767-2775.
10.2337/diabetes.53.11.2767 -
Cerebral insulin increases brain response to glucose
J Neuroendocrinology. 2003-01-01. 15(1) : 75-79.
10.1046/j.1365-2826.2003.00961.x