Pallidal border cells: An anatomical and electrophysiological study in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey

E Bezard, T Boraud, S Chalon, J.M Brotchie, D Guilloteau, C.E Gross
Neuroscience. 2001-02-01; 103(1): 117-123
DOI: 10.1016/S0306-4522(00)00546-7

1. Neuroscience. 2001;103(1):117-23. doi: 10.1016/s0306-4522(00)00546-7.

Pallidal border cells: an anatomical and electrophysiological study in the
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey.

Bezard E(1), Boraud T, Chalon S, Brotchie JM, Guilloteau D, Gross CE.

Author information:
(1)Manchester Movement Disorder Laboratory, Division of Neuroscience, School of
Biological Sciences, University of Manchester, 1.124 Stopford Building,
Manchester M13 9PT, UK.

A dopamine transporter-radioligand binding study demonstrated a dopaminergic
innervation around the pallidal complex in the normal monkey (n=5), i.e. where a
subpopulation of pallidal neurons known as « border cells » is classically
identified. Surprisingly, this peripallidal binding persists in monkeys rendered
parkinsonian (n=5) with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment.
The border cell electrophysiological activity was then analysed in normal and
parkinsonian monkeys (n=2), either in the untreated state or following
administration of levodopa. Pallidal border cell firing frequency was
significantly decreased after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
treatment (8.9+/-0.7 vs 31.4+/-1.6Hz, P