The effect of riluzole on post-traumatic spinal cord injury in the rat
NeuroReport. 1996-01-01; 7(2): 387-392
DOI: 10.1097/00001756-199601310-00003
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1. Neuroreport. 1996 Jan 31;7(2):387-92. doi: 10.1097/00001756-199601310-00003.
The effect of riluzole on post-traumatic spinal cord injury in the rat.
Stutzmann JM(1), Pratt J, Boraud T, Gross C.
Author information:
(1)Neurodegenerative Diseases Department, Rhìne-Poulenc Rorer, CRVA, Vitry,
France.
This study evaluated treatment with riluzole, a neuroprotective agent, following
thoracic spinal cord compression in the rat. Animals received riluzole (2 mg
kg-1) or vehicle twice daily for 10 days following the trauma. Motor deficits,
somatosensory evoked potentials (SEP) and lesion histology were evaluated.
Although paralysis was seen following trauma, seven of 10 animals receiving
riluzole recovered motor function and nearly normal behaviour, unlike animals
receiving vehicle. Trauma dramatically disturbed SEPs with falls in amplitude
and increases in latency. After riluzole SEP returned towards pre-injury levels,
while untreated animals showed no recovery. Morphological studies revealed
significant (53%) reduction in the degree of spinal cord infarcted after
riluzole treatment.
DOI: 10.1097/00001756-199601310-00003
PMID: 8730788 [Indexed for MEDLINE]