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  • Joana Ferreira et Thomas Papouin dans eLife

    20 juin 2017

    des laboratoires de L.Groc et S. Oliet...

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  • Thomas Tourdias et al. dans Brain

    6 juin 2017

    ..démontrer et quantifier la neurodégénérescence.....

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  • Inscription pour le Congrès Inaugural 27-29 Sept 2017

    27 sept. 2017

    ..Registration is mandatory...

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  • Séminaire - Sheena Josselyn & Paul Frankland

    23 juin 2017 à 10:00 - Neurocentre Magendie

    hippocampal neurogenesis contributes...

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  • Christophe Mulle et al. dans Nat Rev Neurosci.

    29 mai 2017

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PUBLICATIONS

Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome.Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome.
Mutations in GPSM2 cause Chudley-McCullough syndrome (CMCS), an autosomal recessive neurological disorder characterized by early-onset sensorineural deafness and brain anomalies. Here, we show that mutation of the mouse orthologue of GPSM2 affects actin-rich stereocilia elongation in auditory and vestibular hair cells, causing deafness and balance defects. The G-protein subunit Gαi3, a well-documented partner of Gpsm2, participates in the elongation process, and its absence also causes hearing deficits. We show that Gpsm2 defines an ∼200 nm nanodomain at the tips of stereocilia and this localization requires the presence of Gαi3, myosin 15 and whirlin. Using single-molecule tracking, we report that loss of Gpsm2 leads to decreased outgrowth and a disruption of actin dynamics in neuronal growth cones. Our results elucidate the aetiology of CMCS and highlight a new molecular role for Gpsm2/Gαi3 in the regulation of actin dynamics in epithelial and neuronal tissues.
Mauriac SA, Hien YE, Bird JE, Carvalho SD, Peyroutou R, Lee SC, Moreau MM, Blanc JM, Geyser A, Medina C, Thoumine O, Beer-Hammer S, Friedman TB, Rüttiger L, Forge A, Nürnberg B, Sans N, Montcouquiol M.

How Hyperarousal and Sleep Reactivity Are Represented in Different Adult Age Groups: Results from a Large Cohort Study on Insomnia.How Hyperarousal and Sleep Reactivity Are Represented in Different Adult Age Groups: Results from a Large Cohort Study on Insomnia.
Hyperarousal is a 24-h state of elevated cognitive and physiological activation, and is a core feature of insomnia. The extent to which sleep quality is affected by stressful events-so-called sleep reactivity-is a vulnerability factor for developing insomnia. Given the increasing prevalence of insomnia with age, we aimed to investigate how hyperarousal and sleep reactivity were related to insomnia severity in different adult age groups. Data were derived from a large cohort study investigating the natural history of insomnia in a population-based sample (n = 1693). Baseline data of the Arousal Predisposition Scale (APS) and Ford Insomnia Response to Stress Test (FIRST) were examined across age and sleep/insomnia subgroups: 25-35 (n = 448), 35-45 (n = 528), and 45-55 year olds (n = 717); good sleepers (n = 931), individuals with insomnia symptoms (n = 450), and individuals with an insomnia syndrome (n = 312). Results from factorial analyses of variance (ANOVA) showed that APS scores decreased with increasing age, but increased with more severe sleep problems. FIRST scores were not significantly different across age groups, but showed the same strong increase as a function of sleep problem severity. The findings indicate that though arousal predisposition and sleep reactivity increase with more severe sleep problems, only arousal decreases with age. How arousing events affect an individual during daytime thus decreases with age, but how this arousal disrupts sleep is equivalent across different adult age groups. The main implication of these findings is that treatment of insomnia could be adapted for different age groups and take into consideration vulnerability factors such as hyperarousal and stress reactivity.
Altena E, Chen IY, Daviaux Y, Ivers H, Philip P, Morin CM.
Brain Sci. 2017 Apr 14

Inducing a long-term potentiation in the dentate gyrus is sufficient to produce rapid antidepressant-like effects.Inducing a long-term potentiation in the dentate gyrus is sufficient to produce rapid antidepressant-like effects.
Recent hypotheses propose that one prerequisite to obtain a rapid antidepressant (AD) effect would reside in processes of synaptic reinforcement occurring within the dentate gyrus (DG) of the hippocampus independently from neurogenesis. However, to date no relationship has been established between an increased DG synaptic plasticity, and rapid AD-like action. To the best of our knowledge, this study shows for the first time that inducing a long-term potentiation (LTP) within the DG by stimulating the perforant pathway (PP) is sufficient to induce such effects. Thus, Sprague-Dawley rats having undergone a successful LTP displayed a significant reduction of immobility when passed acutely 3 days thereafter in the forced swimming test (FST). Further, in a longitudinal paradigm using the pseudo-depressed Wistar-Kyoto rat strain, LTP elicited a decrease of FST immobility after only 2 days, whereas the AD desipramine was not effective before 16 days. In both models, the influence of LTP was transient, as it was no more observed after 8-9 days. No effects were observed on the locomotor activity or on anxiety-related behavior. Theta-burst stimulation of a brain region anatomically adjacent to the PP remained ineffective in the FST. Immunoreactivity of DG cells for phosphorylated histone H3 and doublecortin were not modified three days after LTP, indicating a lack of effect on both cell proliferation and neurogenesis. Finally, depleting brain serotonin contents reduced the success rate of LTP but did not affect its subsequent AD-like effects. These results confirm the 'plastic DG' theory of rapid AD efficacy. Beyond, they point out stimulations of the entorhinal cortex, from which the PP originates, as putative new approaches in AD research.
Kanzari A, Bourcier-Lucas C, Freyssin A, Abrous DN, Haddjeri N, Lucas G.
Mol Psychiatry. 2017 May 9

Operation and plasticity of hippocampal CA3 circuits: implications for memory encodingOperation and plasticity of hippocampal CA3 circuits: implications for memory encoding
The CA3 region of the hippocampus is important for rapid encoding of memory. Computational theories have proposed specific roles in hippocampal function and memory for the sparse inputs from the dentate gyrus to CA3 and for the extended local recurrent connectivity that gives rise to the CA3 autoassociative network. Recently, we have gained considerable new insight into the operation and plasticity of CA3 circuits, including the identification of novel forms of synaptic plasticity and their underlying mechanisms, and structural plasticity in the GABAergic control of CA3 circuits. In addition, experimental links between synaptic plasticity of CA3 circuits and memory are starting to emerge.
Rebola N, Carta M, Mulle C.
Nat Rev Neurosci. 2017 Apr. Review

Optimized labeling of membrane proteins for applications to super-resolution imaging in confined cellular environments using monomeric streptavidin.Optimized labeling of membrane proteins for applications to super-resolution imaging in confined cellular environments using monomeric streptavidin.
Recent progress in super-resolution imaging (SRI) has created a strong need to improve protein labeling with probes of small size that minimize the target-to-label distance, increase labeling density, and efficiently penetrate thick biological tissues. This protocol describes a method for labeling genetically modified proteins incorporating a small biotin acceptor peptide with a 3-nm fluorescent probe, monomeric streptavidin. We show how to express, purify, and conjugate the probe to organic dyes with different fluorescent properties, and how to label selectively biotinylated membrane proteins for SRI techniques (point accumulation in nanoscale topography (PAINT), stimulated emission depletion (STED), stochastic optical reconstruction microscopy (STORM)). This method is complementary to the previously described anti-GFP-nanobody/SNAP-tag strategies, with the main advantage being that it requires only a short 15-amino-acid tag, and can thus be used with proteins resistant to fusion with large tags and for multicolor imaging. The protocol requires standard molecular biology/biochemistry equipment, making it easily accessible for laboratories with only basic skills in cell biology and biochemistry. The production/purification/conjugation steps take ∼5 d, and labeling takes a few minutes to an hour.
Chamma I, Rossier O, Giannone G, Thoumine O, Sainlos M.
Nat Protoc. 2017 Apr

What is an affordance? 40 years laterWhat is an affordance? 40 years later
About 40 years ago, James J. Gibson coined the term "affordance" to describe the action possibilities offered to an animal by the environment with reference to the animal's action capabilities. Since then, this notion has acquired a multitude of meanings, generating confusion in the literature. Here, we offer a clear operationalization of the concept of affordances and related concepts in the field of tool use. Our operationalization is organized around the distinction between the physical (what is objectively observable) and neurocognitive (what is subjectively experienced) levels. This leads us to propose that motor control (dorso-dorsal system), mechanical knowledge (ventro-dorsal system) and function knowledge (ventral system) could be neurocognitive systems respectively involved in the perception of affordances, the understanding of mechanical actions and the storage of contextual relationships (three action-system model; 3AS). We end by turning to two key issues that can be addressed within 3AS. These issues concern the link between affordances and tool incorporation, and the constraints posed by affordances for tool use.
Osiurak F, Rossetti Y, Badets A.
Neurosci Biobehav Rev. 2017 Apr 19. Review

Brèves...

The HUB de Bordeaux

2 juin 2017

The HUB » est une marque créée par l'Université de Bordeaux en partenariat avec le CNRS et l'INSERM entièrement dédiée à l'innovation,► Lire la suite

Obésité et cerveau: matière blanche réduite sans déficit cognitif

13 juin 2017

Les personnes obèses ou en surpoids d'âge moyen présentent un vieillissement cérébral comparable à celui de personnes de poids normal, ayant dix ans d...► Lire la suite

Reconnaissance des visages: le code cérébral déchiffré

9 juin 2017

Nous sommes maintenant capables de ­reconstruire le visage que regarde un singe à partir de l’activité électrique de seulement 205 neurones, dans son ...► Lire la suite

Alcool : le cerveau trinque dès 2 verres par jour

9 juin 2017

Les consommateurs d'alcool, même modérés, sont plus à risque de dommages cérébraux que les autres. Les atrophies d'une zone impliquée dans la cognitio...► Lire la suite

Machine learning: l'effet boite noire....

1 juin 2017

...Le problème, c'est que personne, pas même leurs concepteurs, n'est en mesure d'analyser par quel raisonnement ils arrivent à de si bons résultats.....► Lire la suite

EMPLOIS - JOB OPPORTUNITIES +

Post-doc positions open 
Postdoc in Cortical Plasticity group — Neurocentre Magendie The Cortical Plasticity group at the Neurocentre Magendie (Bordeaux, France) For further information, please contact as soon as possible: Andreas Frick, andreas.frick @ inserm.fr..
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Recherchons ! Bordeaux Neurocampus: 
en ligne le 19 sept 2016 ....Recherchons: Chef de projet du centre  d’excellence sur  les maladies neurodégénératives CHU de Bordeaux Hôpital Pellegrin - Institut des Maladies Neurodégénératives  Lien



Recrutement PhD , ingénieurs , team leader etc...
On line May 9,  2017  /An assistant engineer or “ingenieur d’étude” position is available starting september-october 2017 at the Institute of Cognitive and Integrative Neuroscience of Aquitaine (INCIA), Bordeaux, France. Lien


Recherche d'emploi / Employment sought...

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Job opportunities outside Bordeaux...
 Faculty of Health at Aarhus University, Call for applications........Proposition Poste MCU Poitiers : Le candidat travaillera dans l’équipe NeuroDéveloppement- NeuroAdaptation-NeuroDégénérescence au sein de l’UMR_S 1084 Inserm (LNEC)....
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Le cerveau expliqué aux curieux. Amphi Duguit


"La douleur" avec Virginie Dousset et Marc Landry... 27Juin 19h Place Pey Berland


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le cerveau pour tous


CNS injuries


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Le transfert: un long fleuve tranquille....


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