Memory interaction networks, drugs and stress (MINDS)
Interactions entre émotions et systèmes de mémoire : vieillissement normal et pathologique
Nos travaux s’intéressent à l’impact des émotions positives ou négatives sur les processus mnésiques et les réseaux neuronaux associés. Ces interactions émotions/mémoire sont étudiées en conditions normales et dans certains états pathologiques chroniques tels que le stress, l’alcoolisme, le vieillissement, ou lors de maladies neurodégénératives (Alzheimer). Notre objectif est de mieux caractériser le substrat des effets soit bénéfiques soit pathogéniques des émotions dans le but d’améliorer les processus cognitifs altérés.
English version
Our research is interested in the impact of positive or negative emotions on memory processes and associated neuronal networks. Emotions/memory interactions are studied in normal conditions, but also in chronic pathological states such as stress, alcoholism, aging or during neurodegenerative diseases (Alzheimer). Once the substrates of either beneficial or pathogenic effects of emotions will be better understood, we aim at restoring or improving altered cognitive processes.
Selected publications
- Alcohol withdrawal induces long-lasting spatial working memory impairments: relationship with changes in corticosterone response in the prefrontal cortex.. Gaelle Dominguez, Catherine Belzung, Christophe Pierard, Vincent David, Nadia Henkous, Laurence Decorte, Nicole Mons, Daniel Beracochea. Addiction Biology. 2016-02-10. 22 (4) : 898-910.
- Heads for learning, tails for memory: reward, reinforcement and a role of dopamine in determining behavioral relevance across multiple timescales.. Mathieu Baudonnat, Anna Huber, Vincent David, Mark E. Walton. Front. Neurosci.. 2013-01-01. 7
- Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement. S Tolu, R Eddine, F Marti, V David, M Graupner, S Pons, M Baudonnat, M Husson, M Besson, C Reperant, J Zemdegs, C Pagès, Y A H Hay, B Lambolez, J Caboche, B Gutkin, A M Gardier, J-P Changeux, P Faure, U Maskos. Mol Psychiatry. 2012-07-03. 18 (3) : 382-393.
- Distinct contributions of nicotinic acetylcholine receptor subunit alpha4 and subunit alpha6 to the reinforcing effects of nicotine.. R. Exley, N. Maubourguet, V. David, R. Eddine, A. Evrard, S. Pons, F. Marti, S. Threlfell, P. Cazala, J. M. McIntosh, J.-P. Changeux, U. Maskos, S. J. Cragg, P. Faure. Proceedings of the National Academy of Sciences. 2011-04-18. 108 (18) : 7577-7582.
- Brain regional Fos expression elicited by the activation of mu- but not delta-opioid receptors of the ventral tegmental area: evidence for an implication of the ventral thalamus in opiate reward.. Vincent David, Audrey Matifas, Stéphanie Gavello-Baudy, Laurence Decorte, Brigitte L Kieffer, Pierre Cazala. Neuropsychopharmacol. 2007-09-26. 33 (7) : 1746-1759.
- Long-term effects of chronic nicotine exposure on brain nicotinic receptors.. M. Besson, S. Granon, M. Mameli-Engvall, I. Cloez-Tayarani, N. Maubourguet, A. Cormier, P. Cazala, V. David, J.-P. Changeux, P. Faure. Proceedings of the National Academy of Sciences. 2007-04-30. 104 (19) : 8155-8160.
- Reinforcing effects of nicotine microinjections into the ventral tegmental area of mice: Dependence on cholinergic nicotinic and dopaminergic D1 receptors. Vincent David, Morgane Besson, Jean-Pierre Changeux, Sylvie Granon, Pierre Cazala. Neuropharmacology. 2006-06-01. 50 (8) : 1030-1040.
- Targeted in vivo expression of nicotinic acetylcholine receptors in mouse brain using lentiviral expression vectors.. B. E. Molles, U. Maskos, S. Pons, M. Besson, P. Guiard, J.-P. Guilloux, A. Evrard, A. Cormier, M. Mameli-Engvall, I. Cloëz-Tayarani, H. Nakatani, N. Dufour, A.-P. Bemelmans, J. Mallet, P. Cazala, A. M. Gardier, V. David, P. Faure, S. Granon, J.-P. Changeux. JMN. 2006-01-01. 30 (1-2) : 105-106.
- Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors. U. Maskos, B. E. Molles, S. Pons, M. Besson, B. P. Guiard, J.-P. Guilloux, A. Evrard, P. Cazala, A. Cormier, M. Mameli-Engvall, N. Dufour, I. Cloëz-Tayarani, A.-P. Bemelmans, J. Mallet, A. M. Gardier, V. David, P. Faure, S. Granon, J.-P. Changeux. Nature. 2005-07-01. 436 (7047) : 103-107.
Chef(s) d'équipe
Membres de l'équipe
Personnel(s) de recherche
Jacques Micheau
Micheau
(Enseignant-chercheur)
Jean-Louis Guillou Guillou (Enseignant-chercheur)
Marc Corio Corio (Enseignant-chercheur)
Nicole Mons Mons (Chercheur)
Jean-Louis Guillou Guillou (Enseignant-chercheur)
Marc Corio Corio (Enseignant-chercheur)
Nicole Mons Mons (Chercheur)
Personnel(s) technique
Nadia Henkous
Henkous
Post-doctorant(s)
Doctorant(s)