David Perrais

Publications

• Author Correction: Endocytosis in the axon initial segment maintains neuronal polarity
  Kelsie Eichel, Takeshi Uenaka, Vivek Belapurkar, Rui Lu, Shouqiang Cheng, Joseph S. Pak, Caitlin A. Taylor, Thomas C. Südhof, Robert Malenka, Marius Wernig, Engin Özkan, David Perrais, Kang Shen.
  Nature. 2025-03-18.
  10.1038/s41586-025-08837-y
• Emerging role of oncogenic ß-catenin in exosome biogenesis as a driver of immune escape in hepatocellular carcinoma
  Camille Dantzer, Justine Vaché, Aude Brunel, Isabelle Mahouche, Anne-Aurélie Raymond, Jean-William Dupuy, Melina Petrel, Paulette Bioulac-Sage, David Perrais, Nathalie Dugot-Senant, Mireille Verdier, Barbara Bessette, Clotilde Billottet, Violaine Moreau.
  eLife. 2024-07-15. 13
  10.7554/eLife.95191.3
• Synaptotagmin 1-triggered lipid signaling facilitates coupling of exo- and endocytosis
  Svenja Bolz, Natalie Kaempf, Dmytro Puchkov, Michael Krauss, Giulia Russo, Tolga Soykan, Christopher Schmied, Martin Lehmann, Rainer Müller, Carsten Schultz, David Perrais, Tanja Maritzen, Volker Haucke.
  Neuron. 2023-09-01.
  10.1016/j.neuron.2023.08.016
• Imaging of post-synaptic membrane trafficking in neuronal dendrites: progress, limitations, and new developments
  David Perrais, Silvia Sposini, Julie Angibaud.
  Neurophoton.. 2023-08-04. 10(04)
  10.1117/1.nph.10.4.044404
• Rational Engineering of an Improved Genetically Encoded pH Sensor Based on Superecliptic pHluorin
  Yi Shen, Yurong Wen, Silvia Sposini, Anjali Amrapali Vishwanath, Ahmed S. Abdelfattah, Eric R. Schreiter, M. Joanne Lemieux, Jaime de Juan-Sanz, David Perrais, Robert E. Campbell.
  ACS Sens.. 2023-07-23. 8(8) : 3014-3022.
  10.1021/acssensors.3c00484
• Cellular and structural insight into dynamin function during endocytic vesicle formation: a tale of 50 years of investigation
  David Perrais.
  Bioscience Reports. 2022-11-01. 42(11)
  10.1042/BSR20211227
• Endocytosis in the axon initial segment maintains neuronal polarity
  Kelsie Eichel, Takeshi Uenaka, Vivek Belapurkar, Rui Lu, Shouqiang Cheng, Joseph S. Pak, Caitlin A. Taylor, Thomas C. Südhof, Robert Malenka, Marius Wernig, Engin Özkan, David Perrais & Kang Shen.
  Nature. 2022-08-17. 609 : 128-135.
  10.1038/s41586-022-05074-5
• Alix is required for activity-dependent bulk endocytosis at brain synapses
  Marine H. Laporte, Kwang Il Chi, Laura C. Caudal, Na Zhao, Yvonne Schwarz, Marta Rolland, José Martinez-Hernandez, Magalie Martineau, Christine Chatellard, Eric Denarier, Vincent Mercier, Florent Lemaître, Béatrice Blot, Eve Moutaux, Maxime Cazorla, David Perrais, Fabien Lanté, Dieter Bruns, Sandrine Fraboulet, Fiona J. Hemming, Frank Kirchhoff, Rémy Sadoul.
  PLoS Biol. 2022-06-03. 20(6) : e3001659.
  10.1371/journal.pbio.3001659
• A synaptomic analysis reveals dopamine hub synapses in the mouse striatum
  Vincent Paget-Blanc, Marlene E. Pfeffer, Marie Pronot, Paul Lapios, Maria-Florencia Angelo, Roman Walle, Fabrice P. Cordelières, Florian Levet, Stéphane Claverol, Sabrina Lacomme, Mélina Petrel, Christelle Martin, Vincent Pitard, Véronique De Smedt Peyrusse, Thomas Biederer, David Perrais, Pierre Trifilieff, Etienne Herzog.
  Nat Commun. 2022-06-03. 13(1)
  10.1038/s41467-022-30776-9
• Selective endocytosis of Ca ²⁺ -permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity
  Domenico Azarnia Tehran, Gaga Kochlamazashvili, Niccolò P. Pampaloni, Silvia Sposini, Jasmeet Kaur Shergill, Martin Lehmann, Natalya Pashkova, Claudia Schmidt, Delia Löwe, Hanna Napieczynska, Arnd Heuser, Andrew J. R. Plested, David Perrais, Robert C. Piper, Volker Haucke, Tanja Maritzen.
  Sci. Adv.. 2022-05-27. 8(21)
  10.1126/sciadv.abl5032
• Selective endocytosis of Ca²⁺-permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity
  Domenico Azarnia Tehran, Gaga Kochlamazashvili, Niccolò P. Pampaloni, Silvia Sposini, Jasmeet Kaur Shergill, Martin Lehmann, Natalya Pashkova, Claudia Schmidt, Delia Löwe, Hanna Napieczynska, Arnd Heuser, Andrew J. R. Plested, David Perrais, Robert C. Piper, Volker Haucke, Tanja Maritzen.
  Sci. Adv.. 2022-05-27. 8(21)
  10.1126/sciadv.abl5032
• Live cell tracking of macrophage efferocytosis during Drosophila embryo development in vivo
  Michael H. Raymond, Andrew J. Davidson, Yi Shen, Daniel R. Tudor, Christopher D. Lucas, Sho Morioka, Justin S. A. Perry, Julia Krapivkina, David Perrais, Linus J. Schumacher, Robert E. Campbell, Will Wood, Kodi S. Ravichandran.
  Science. 2022-03-11. 375(6585) : 1182-1187.
  10.1126/science.abl4430
• Bioorthogonal labeling of transmembrane proteins with non-canonical amino acids unveils masked epitopes in live neurons
  Diogo Bessa-Neto, Gerti Beliu, Alexander Kuhlemann, Valeria Pecoraro, Sören Doose, Natacha Retailleau, Nicolas Chevrier, David Perrais, Markus Sauer, Daniel Choquet.
  Nat Commun. 2021-11-18. 12(1)
  10.1038/s41467-021-27025-w
• The vSNAREs VAMP2 and VAMP4 control recycling and intracellular sorting of post-synaptic receptors in neuronal dendrites
  May Bakr, Damien Jullié, Julia Krapivkina, Vincent Paget-Blanc, Lou Bouit, Jennifer D. Petersen, Natacha Retailleau, Christelle Breillat, Etienne Herzog, Daniel Choquet, David Perrais.
  Cell Reports. 2021-09-01. 36(10) : 109678.
  10.1016/j.celrep.2021.109678
• NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95
  Benjamin Compans, Come Camus, Emmanouela Kallergi, Silvia Sposini, Magalie Martineau, Corey Butler, Adel Kechkar, Remco V. Klaassen, Natacha Retailleau, Terrence J. Sejnowski, August B. Smit, Jean-Baptiste Sibarita, Thomas M. Bartol, David Perrais, Vassiliki Nikoletopoulou, Daniel Choquet, Eric Hosy.
  Nat Commun. 2021-05-14. 12(1)
  10.1038/s41467-021-23133-9
• Bioorthogonal labeling of transmembrane proteins with non-canonical amino acids allows access to masked epitopes in live neurons
  Diogo Bessa-Neto, Alexander Kuhlemann, Gerti Beliu, Valeria Pecoraro, Sören Doose, Natacha Retailleau, Nicolas Chevrier, David Perrais, Markus Sauer, Daniel Choquet.
  . 2021-02-27.
  10.1101/2021.02.27.433189
• Pharmacological Programming of Endosomal Signaling Activated by Small Molecule Ligands of the Follicle Stimulating Hormone Receptor.
  Silvia Sposini, Francesco De Pascali, Rachel Richardson, Niamh S. Sayers, David Perrais, Henry N. Yu, Stephen Palmer, Selva Nataraja, Eric Reiter, Aylin C. Hanyaloglu.
  Front. Pharmacol.. 2020-11-30. 11
  10.3389/fphar.2020.593492
• Imaging endocytic vesicle formation at high spatial and temporal resolutions with the pulsed-pH protocol
  Silvia Sposini, Morgane Rosendale, Léa Claverie, Thi Nhu Ngoc Van, Damien Jullié, David Perrais.
  Nat Protoc. 2020-08-17. 15(9) : 3088-3104.
  10.1038/s41596-020-0371-z
• Functional recruitment of dynamin requires multimeric interactions for efficient endocytosis
  Morgane Rosendale, Thi Nhu Ngoc Van, Dolors Grillo-Bosch, Silvia Sposini, Léa Claverie, Isabel Gauthereau, Stéphane Claverol, Daniel Choquet, Matthieu Sainlos, David Perrais.
  Nat Commun. 2019-10-01. 10(1)
  10.1038/s41467-019-12434-9
• Exchange Dynamics of Dynamin Measured in Living Cells During Endocytic Vesicle Formation
  Léa Claverie, Morgane Rosendale, Patrice Maschalchi, Corey Butler, Natacha Retailleau, Jean-Baptiste Sibarita, Daniel Choquet, David Perrais.
  Microsc Microanal. 2019-08-01. 25(S2) : 1240-1241.
  10.1017/S1431927619006937
• Endocytose dans les dendrites: un outil local de régulation de la transmission synaptique
  .
  Med Sci. 2017-11. 33(11) : 942-945.
  10.1051/medsci/20173311009
• Imaging in focus: Imaging the dynamics of endocytosis
  Morgane Rosendale, David Perrais.
  The International Journal of Biochemistry & Cell Biology. 2017-12. 93 : 41-45.
  10.1016/j.biocel.2017.10.010
• Semisynthetic fluorescent pH sensors for imaging exocytosis and endocytosis
  Magalie Martineau, Agila Somasundaram, Jonathan B. Grimm, Todd D. Gruber, Daniel Choquet, Justin W. Taraska, Luke D. Lavis, David Perrais.
  Nat Commun. 2017-11-10. 8(1)
  10.1038/s41467-017-01752-5
• A Central Small Amino Acid in the VAMP2 Transmembrane Domain Regulates the Fusion Pore in Exocytosis
  Benoît Hastoy, Pier A. Scotti, Alexandra Milochau, Zahia Fezoua-Boubegtiten, Jorge Rodas, Rémi Megret, Bernard Desbat, Michel Laguerre, Sabine Castano, David Perrais, Patrik Rorsman, Reiko Oda, Jochen Lang.
  Sci Rep. 2017-06-06. 7(1)
  10.1038/s41598-017-03013-3
• Spatial and Temporal Regulation of Receptor Endocytosis in Neuronal Dendrites Revealed by Imaging of Single Vesicle Formation.
  Morgane Rosendale, Damien Jullié, Daniel Choquet, David Perrais.
  Cell Reports. 2017-02-01. 18(8) : 1840-1847.
  10.1016/j.celrep.2017.01.081
• Rab35 GTPase Triggers Switch-like Recruitment of the Lowe Syndrome Lipid Phosphatase OCRL on Newborn Endosomes.
  Clothilde Cauvin, Morgane Rosendale, Neetu Gupta-Rossi, Murielle Rocancourt, Pierre Larraufie, Rémi Salomon, David Perrais, Arnaud Echard.
  Current Biology. 2016-01-01. 26(1) : 120-128.
  10.1016/j.cub.2015.11.040
• Mechanical coupling between transsynaptic N-cadherin adhesions and actin flow stabilizes dendritic spines.
  Anaël Chazeau, Mikael Garcia, Katalin Czöndör, David Perrais, Béatrice Tessier, Grégory Giannone, Olivier Thoumine.
  MBoC. 2015-03-01. 26(5) : 859-873.
  10.1091/mbc.E14-06-1086
• pHuji, a pH-sensitive red fluorescent protein for imaging of exo- and endocytosis.
  Yi Shen, Morgane Rosendale, Robert E. Campbell, David Perrais.
  J Cell Biol. 2014-11-10. 207(3) : 419-432.
  10.1083/jcb.201404107
• Recycling endosomes undergo rapid closure of a fusion pore on exocytosis in neuronal dendrites.
  D. Jullie, D. Choquet, D. Perrais.
  Journal of Neuroscience. 2014-08-13. 34(33) : 11106-11118.
  10.1523/jneurosci.0799-14.2014
• Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia.
  Pedro Monteiro, Carine Rossé, Antonio Castro-Castro, Marie Irondelle, Emilie Lagoutte, Perrine Paul-Gilloteaux, Claire Desnos, Etienne Formstecher, François Darchen, David Perrais, Alexis Gautreau, Maud Hertzog, Philippe Chavrier.
  J Cell Biol. 2013-12-16. 203(6) : 1063-1079.
  10.1083/jcb.201306162
• Agonist-dependent endocytosis of γ-aminobutyric acid type A (GABAA) receptors revealed by a γ2(R43Q) epilepsy mutation.
  Severine Chaumont, Caroline André, David Perrais, Eric Boué-Grabot, Antoine Taly, Maurice Garret.
  J. Biol. Chem.. 2013-08-09. 288(39) : 28254-28265.
  10.1074/jbc.M113.470807
• Zinc potentiates GluK3 glutamate receptor function by stabilizing the ligand binding domain dimer interface.
  Julien Veran, Janesh Kumar, Paulo S. Pinheiro, Axel Athané, Mark L. Mayer, David Perrais, Christophe Mulle.
  Neuron. 2012-11-01. 76(3) : 565-578.
  10.1016/j.neuron.2012.08.027
• Selective block of postsynaptic kainate receptors reveals their function at hippocampal mossy fiber synapses.
  Paulo S. Pinheiro, Frédéric Lanore, Julien Veran, Julien Artinian, Christophe Blanchet, Valérie Crépel, David Perrais, Christophe Mulle.
  Cerebral Cortex. 2012-02-17. 23(2) : 323-331.
  10.1093/cercor/bhs022
• Endocytosis of the glutamate receptor subunit GluK3 controls polarized trafficking
  D. Huyghe, J. Veran, V. F. Labrousse, D. Perrais, C. Mulle, F. Coussen.
  Journal of Neuroscience. 2011-08-10. 31(32) : 11645-11654.
  10.1523/JNEUROSCI.2206-11.2011
• SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism.
  C M Durand, J Perroy, F Loll, D Perrais, L Fagni, T Bourgeron, M Montcouquiol, N Sans.
  Mol Psychiatry. 2011-05-24. 17(1) : 71-84.
  10.1038/mp.2011.57
• A high precision survey of the molecular dynamics of mammalian clathrin-mediated endocytosis.
  Marcus J. Taylor, David Perrais, Christien J. Merrifield.
  PLoS Biol. 2011-03-22. 9(3) : e1000604.
  10.1371/journal.pbio.1000604
• Gating and permeation of kainate receptors: differences unveiled.
  David Perrais, Julien Veran, Christophe Mulle.
  Trends in Pharmacological Sciences. 2010-11-01. 31(11) : 516-522.
  10.1016/j.tips.2010.08.004
• Atypical functional properties of GluK3-containing kainate receptors
  D. Perrais, F. Coussen, C. Mulle.
  Journal of Neuroscience. 2009-12-09. 29(49) : 15499-15510.
  10.1523/JNEUROSCI.2724-09.2009
• Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity.
  Renato Frischknecht, Martin Heine, David Perrais, Constanze I Seidenbecher, Daniel Choquet, Eckart D Gundelfinger.
  Nat Neurosci. 2009-05-31. 12(7) : 897-904.
  10.1038/nn.2338
• Antagonism of recombinant and native GluK3-containing kainate receptors.
  David Perrais, Paulo S. Pinheiro, David E. Jane, Christophe Mulle.
  Neuropharmacology. 2009-01-01. 56(1) : 131-140.
  10.1016/j.neuropharm.2008.08.002
• Human GluR6c, a functional splicing variants of GluR6, is mainly expressed in non-nervous cells.
  Alessandro Barbon, Annalisa Gervasoni, Luca LaVia, Cesare Orlandi, Frédéric Jaskolski, David Perrais, Sergio Barlati.
  Neuroscience Letters. 2008-03-01. 434(1) : 77-82.
  10.1016/j.neulet.2008.01.049
• Shiga toxin induces tubular membrane invaginations for its uptake into cells.
  Winfried Römer, Ludwig Berland, Valérie Chambon, Katharina Gaus, Barbara Windschiegl, Danièle Tenza, Mohamed R. E. Aly, Vincent Fraisier, Jean-Claude Florent, David Perrais, Christophe Lamaze, Graça Raposo, Claudia Steinem, Pierre Sens, Patricia Bassereau, Ludger Johannes.
  Nature. 2007-11-01. 450(7170) : 670-675.
  10.1038/nature05996
• Imaging Exocytosis with Total Internal Reflection Microscopy (TIRFM).
  David Zenisek, David Perrais.
  Cold Spring Harb Protoc. 2007-10-01. 2007(10) : pdb.prot4863.
  10.1101/pdb.prot4863
• Principles of Total Internal Reflection Microscopy (TIRFM).
  David Zenisek, David Perrais.
  Cold Spring Harb Protoc. 2007-10-01. 2007(10) : pdb.top24.
  10.1101/pdb.top24
• Fast regulation of axonal growth cone motility by electrical activity
  G. Ibarretxe, D. Perrais, F. Jaskolski, A. Vimeney, C. Mulle.
  Journal of Neuroscience. 2007-07-18. 27(29) : 7684-7695.
  10.1523/JNEUROSCI.1070-07.2007
• GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses.
  P. S. Pinheiro, D. Perrais, F. Coussen, J. Barhanin, B. Bettler, J. R. Mann, J. O. Malva, S. F. Heinemann, C. Mulle.
  Proceedings of the National Academy of Sciences. 2007-07-09. 104(29) : 12181-12186.
  10.1073/pnas.0608891104
• Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses
  N. Rebola, S. Sachidhanandam, D. Perrais, R. A. Cunha, C. Mulle.
  Journal of Neuroscience. 2007-04-11. 27(15) : 3987-3993.
  10.1523/JNEUROSCI.5182-06.2007
• Dynamics of endocytic vesicle creation.
  David Perrais, Christien J. Merrifield.
  Developmental Cell. 2005-11-01. 9(5) : 581-592.
  10.1016/j.devcel.2005.10.002
• Co-assembly of two GluR6 kainate receptor splice variants within a functional protein complex.
  Françoise Coussen, David Perrais, Frédéric Jaskolski, Shankar Sachidhanandam, Elisabeth Normand, Joel Bockaert, Philippe Marin, Christophe Mulle.
  Neuron. 2005-08-01. 47(4) : 555-566.
  10.1016/j.neuron.2005.06.033
• Coupling between clathrin-coated-pit invagination, cortactin recruitment, and membrane scission observed in live cells.
  Christien J. Merrifield, David Perrais, David Zenisek.
  Cell. 2005-05-01. 121(4) : 593-606.
  10.1016/j.cell.2005.03.015
• Recapture after exocytosis causes differential retention of protein in granules of bovine chromaffin cells.
  David Perrais, Ingo C. Kleppe, Justin W. Taraska, Wolfhard Almers.
  The Journal of Physiology. 2004-10-01. 560(2) : 413-428.
  10.1113/jphysiol.2004.064410
• Secretory granules are recaptured largely intact after stimulated exocytosis in cultured endocrine cells.
  J. W. Taraska, D. Perrais, M. Ohara-Imaizumi, S. Nagamatsu, W. Almers.
  Proceedings of the National Academy of Sciences. 2003-01-21. 100(4) : 2070-2075.
  10.1073/pnas.0337526100
• Altering the concentration of GABA in the synaptic cleft potentiates miniature IPSCs in rat occipital cortex.
  David Perrais, Nicole Ropert.
  European Journal of Neuroscience. 2000-01-01. 12(1) : 400-404.
  10.1046/j.1460-9568.2000.00957.x
• Expression of GABA(A) receptor subunit mRNAs by layer V pyramidal cells of the rat primary visual cortex.
  Diego Ruano, David Perrais, Jean Rosier, Nicole Ropert.
  European Journal of Neuroscience. 1997-04-01. 9(4) : 857-862.
  10.1111/j.1460-9568.1997.tb01435.x
• Correlation between kinetics and RNA splicing of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in neocortical neurons.
  B. Lambolez, N. Ropert, D. Perrais, J. Rossier, S. Hestrin.
  Proceedings of the National Academy of Sciences. 1996-03-05. 93(5) : 1797-1802.
  10.1073/pnas.93.5.1797
• Diversity of glutamate receptors in neocortical neurons: implications for synaptic plasticity.
  E Audinat, B Lambolez, B Cauli, N Ropert, D Perrais, S Hestrin, J Rossier.
  Journal of Physiology-Paris. 1996-01-01. 90(5-6) : 331-332.
  10.1016/S0928-4257(97)87911-9