Bruno Bontempi

Publications

• Early intrinsic excitability plasticity of neocortical engram neurons defines memory formation and precision
  Senka Hadzibegovic, Liangying Zhu, Melanie Ginger, Maria Gueidão Costa, Paula Alvarez Menendez, Rafaël De Sa, Katy Le Corf, Yves Le Feuvre, Olivier Nicole, Bruno Bontempi, Andreas Frick.
  Nature Communications. 2025-12-05. 17(1)
  10.1038/s41467-025-66975-3
• A novel Y-maze paradigm with enhanced sensitivity to subtle spatial recognition memory impairments in mice
  Senka Hadzibegovic, Bruno Bontempi, Olivier Nicole.
  BMC Methods. 2025-10-01. 2(1)
  10.1186/s44330-025-00043-6
• Normal and slow learners: a new discriminative method based on the speed of spatial learning in aged mice
  Céline Duffau, Senka Hadzibegovic, Vojislav Andelkovic, Bruno Bontempi, Olivier Nicole.
  Front. Aging Neurosci.. 2025-06-06. 17
  10.3389/fnagi.2025.1567929
• Examining the effects of extremely low-frequency magnetic fields on cognitive functions and functional brain markers in aged mice.
  Senka Hadzibegovic, Olivier Nicole, Vojislav Andelkovic, Florence Poulletier de Gannes, Annabelle Hurtier, Isabelle Lagroye, Bruno Bontempi.
  Sci Rep. 2025-03-11. 15(1)
  10.1038/s41598-025-93230-y
• Investigating the Impact of NMDA Receptor Organization and Biological Sex in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease
  Senka Hadzibegovic, Bruno Bontempi, Olivier Nicole.
  IJMS. 2025-02-18. 26(4) : 1737.
  10.3390/ijms26041737
• Therapeutic efficacy of the BKCa channel opener chlorzoxazone in a mouse model of Fragile X syndrome
  Celeste Ferraguto, Marion Piquemal-Lagoueillat, Valerie Lemaire, Maïté M. Moreau, Stefania Trazzi, Beatrice Uguagliati, Elisabetta Ciani, Sandrine S. Bertrand, Eric Louette, Bruno Bontempi, Susanna Pietropaolo.
  Neuropsychopharmacol.. 2024-09-02.
  10.1038/s41386-024-01956-6
• Synaptic rearrangement of NMDA receptors controls memory engram formation and malleability in the cortex
  Benjamin Bessières, Julien Dupuis, Laurent Groc, Bruno Bontempi, Olivier Nicole.
  Sci. Adv.. 2024-08-30. 10(35)
  10.1126/sciadv.ado1148
• Physical exercise restores adult neurogenesis deficits induced by simulated microgravity
  Alexandra Gros, Fandilla Marie Furlan, Vanessa Rouglan, Alexandre Favereaux, Bruno Bontempi, Jean-Luc Morel.
  npj Microgravity volume. 2024-06-21. 10(69)
  10.1038/s41526-024-00411-6
• Early Administration of the Phytocannabinoid Cannabidivarin Prevents the Neurobehavioral Abnormalities Associated with the Fmr1-KO Mouse Model of Fragile X Syndrome
  Marika Premoli, William Fyke, Luigi Bellocchio, Valerie Lemaire, Marie Wolley-Roberts, Bruno Bontempi, Susanna Pietropaolo.
  Cells. 2023-07-25. 12(15) : 1927.
  10.3390/cells12151927
• Targeting Pdzrn3 maintains adult blood-brain barrier and central nervous system homeostasis
  Florian Gueniot, Sebastien Rubin, Pauline Bougaran, Alice Abelanet, Jean Luc Morel, Bruno Bontempi, Carole Proust, Pascale Dufourcq, Thierry Couffinhal, Cecile Duplàa.
  J Cereb Blood Flow Metab. 2021-10-13. : 0271678X2110489.
  10.1177/0271678X211048981
• Increased surface P2X4 receptor regulates anxiety and memory in P2X4 internalization-defective knock-in mice
  Eléonore Bertin, Thomas Deluc, Kjara S. Pilch, Audrey Martinez, Johan-Till Pougnet, Evelyne Doudnikoff, Anne-Emilie Allain, Philine Bergmann, Marion Russeau, Estelle Toulmé, Erwan Bezard, Friedrich Koch-Nolte, Philippe Séguéla, Sabine Lévi, Bruno Bontempi, François Georges, Sandrine S. Bertrand, Olivier Nicole, Eric Boué-Grabot.
  Mol Psychiatry. 2020-01-08.
  10.1038/s41380-019-0641-8
• The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline.
  David Castonguay, Julien Dufort-Gervais, Caroline Ménard, Manavi Chatterjee, Rémi Quirion, Bruno Bontempi, Jay S. Schneider, Amy F.T. Arnsten, Angus C. Nairn, Christopher M. Norris, Guylaine Ferland, Erwan Bézard, Pierrette Gaudreau, Paul J. Lombroso, Jonathan Brouillette.
  Current Biology. 2018-04-01. 28(7) : 1079-1089.e4.
  10.1016/j.cub.2018.02.047
• Assessing recent and remote associative olfactory memory in rats using the social transmission of food preference paradigm
  Benjamin Bessières, Olivier Nicole, Bruno Bontempi.
  Nat Protoc. 2017-06-22. 12(7) : 1415-1436.
  10.1038/nprot.2017.050
• Soluble amyloid beta oligomers block the learning-induced increase in hippocampal sharp wave-ripple rate and impair spatial memory formation
  Olivier Nicole, Senka Hadzibegovic, Judyta Gajda, Bruno Bontempi, Tiaza Bem, Pierre Meyrand.
  Sci Rep. 2016-03-07. 6(1)
  10.1038/srep22728
• Reduced cytochrome oxidase activity in the retrosplenial cortex after lesions to the anterior thalamic nuclei.
  Magdalena Mendez-Lopez, Jorge L. Arias, Bruno Bontempi, Mathieu Wolff.
  Behavioural Brain Research. 2013-08-01. 250 : 264-273.
  10.1016/j.bbr.2013.04.052
• Tiny light, big hope
  Benjamin Bessieres, Bruno Bontempi, Olivier Nicole.
  Mov Disord.. 2013-08-01. 28(9) : 1210-1210.
  10.1002/mds.25530
• Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity
  F. El Gaamouch, A. Buisson, O. Moustie, M. Lemieux, S. Labrecque, B. Bontempi, P. De Koninck, O. Nicole.
  Journal of Neuroscience. 2012-08-01. 32(31) : 10767-10779.
  10.1523/JNEUROSCI.5622-11.2012
• Early Tagging of Cortical Networks Is Required for the Formation of Enduring Associative Memory
  Edith Lesburguères, Oliviero L. Gobbo, Stéphanie Alaux-Cantin, Anne Hambucken, Pierre Trifilieff, Bruno Bontempi.
  Science. 2011-02-18. 331(619) : 924-928.
  10.1126/science.1196164
• Early tagging of cortical networks is required for the formation of enduring associative memory.
  E. Lesburgueres, O. L. Gobbo, S. Alaux-Cantin, A. Hambucken, P. Trifilieff, B. Bontempi.
  Science. 2011-02-17. 331(6019) : 924-928.
  10.1126/science.1196164
• The Intralaminar Thalamic Nuclei Contribute to Remote Spatial Memory
  J. Lopez, M. Wolff, L. Lecourtier, B. Cosquer, B. Bontempi, J. Dalrymple-Alford, J.-C. Cassel.
  Journal of Neuroscience. 2009-03-11. 29(10) : 3302-3306.
  10.1523/jneurosci.5576-08.2009