Agnès Nadjar
Responsable d'équipe / Professeure
Professeure / Université de Bordeaux/ Équipe
Neuroimmunologie des pathologies et de la santé métabolique (NOMAD) (Nadjar )
Institut des Maladies Neurodégénératives
/ Contact
www.orcid.org/0000-0002-3969-6530
Je m’intéresse depuis toujours aux interactions neuroimmunes et à leur modulation par l’environnement. Aujourd’hui, mon équipe étudie comment les cellules immunitaires du cerveau — microglies et immunité méningée — régulent le métabolisme énergétique, dans l’objectif de tirer parti de ces mécanismes pour prévenir ou ralentir des maladies neurodégénératives comme Alzheimer, qui s’accompagnent de profondes perturbations métaboliques.
Axes de recherche
Axe principal
Axe secondaire
Publications
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Nuclear factor κB nuclear translocation as a crucial marker of brain response to interleukin-1. A study in rat and interleukin-1 type I deficient mouse
Journal of Neurochemistry. 2004-02-04. 87(4) : 1024-1036.
10.1046/j.1471-4159.2003.02097.x -
Inactivation of the Cerebral NFκB Pathway Inhibits Interleukin-1β-Induced Sickness Behavior and c-Fos Expression in Various Brain Nuclei
Neuropsychopharmacol. . 30(8) : 1492-1499.
10.1038/sj.npp.1300755 -
Subthalamic stimulation increases striatal tyrosine hydroxylase phosphorylation
NeuroReport. 2008-01-01. 19(2) : 179-182.
10.1097/WNR.0b013e3282f417b4 -
RGS9-2 negatively modulates L-3,4-dihydroxyphenylalanine-induced dyskinesia in experimental Parkinson’s disease.
Journal of Neuroscience. 2007-12-26. 27(52) : 14338-14348.
10.1523/jneurosci.4223-07.2007 -
IGF-1 signaling reduces neuro-inflammatory response and sensitivity of neurons to MPTP.
Neurobiology of Aging. 2009-12-01. 30(12) : 2021-2030.
10.1016/j.neurobiolaging.2008.02.009 -
The 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor lovastatin reduces severity of L-DOPA-induced abnormal involuntary movements in experimental Parkinson’s disease.
Journal of Neuroscience. 2008-04-23. 28(17) : 4311-4316.
10.1523/jneurosci.4720-07.2008 -
Interleukin-6 activates arginine vasopressin neurons in the supraoptic nucleus during immune challenge in rats
American Journal of Physiology-Endocrinology and Metabolism. . 296(6) : E1289-E1299.
10.1152/ajpendo.90489.2008 -
Priming for l-dopa-induced dyskinesia in Parkinson’s disease: a feature inherent to the treatment or the disease?
Progress in Neurobiology. 2009-01-01. 87(1) : 1-9.
10.1016/j.pneurobio.2008.09.013 -
Brain cyclooxygenase-2 mediates interleukin-1-induced cellular activation in preoptic and arcuate hypothalamus, but not sickness symptoms.
Neurobiology of Disease. 2010-09-01. 39(3) : 393-401.
10.1016/j.nbd.2010.05.005 -
High frequency stimulation of the entopeduncular nucleus sets the cortico-basal ganglia network to a new functional state in the dystonic hamster.
Neurobiology of Disease. 2009-09-01. 35(3) : 399-405.
10.1016/j.nbd.2009.05.022 -
Evolution of the dynamic properties of the cortex-basal ganglia network after dopaminergic depletion in rats
Neurobiology of Disease. 2012-05-01. 46(2) : 402-413.
10.1016/j.nbd.2012.02.004 -
Short-term long chain Omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice
PLoS ONE. 2012-05-25. 7(5) : e36861.
10.1371/journal.pone.0036861 -
Early morphofunctional plasticity of microglia in response to acute lipopolysaccharide
Brain, Behavior, and Immunity. 2013-11-01. 34 : 151-158.
10.1016/j.bbi.2013.08.008 -
Astrocyte-derived adenosine modulates increased sleep pressure during inflammatory response
Glia. 2013-02-04. 61(5) : 724-731.
10.1002/glia.22465 -
N-3 LCPUFA improves cognition: The young, the old and the sick
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2014-07-01. 91(1-2) : 1-20.
10.1016/j.plefa.2014.05.001 -
Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging
PLoS ONE. 2014-02-05. 9(2) : e87421.
10.1371/journal.pone.0087421 -
N-3 polyunsaturated fatty acid and neuroinflammation in aging: Role in cognition
Pharma-Nutrition. 2014-01-01. : 91-112.
10.1007/978-3-319-06151-1_6 -
Nutritional n-3 PUFAs deficiency during perinatal periods alters brain innate immune system and neuronal plasticity-associated genes
Brain, Behavior, and Immunity. 2014-10-01. 41 : 22-31.
10.1016/j.bbi.2014.03.021 -
Transgenic increase in n-3/n-6 fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation
Neuropsychopharmacol. 2014-08-05. 40(3) : 525-536.
10.1038/npp.2014.196 -
N-3 polyunsaturated fatty acid and neuroinflammation in aging and Alzheimer’s disease
NUA. . 3(1) : 33-47.
10.3233/nua-150049 -
Role of n-3 PUFAs in inflammation via resolvin biosynthesis
OCL. 2015-12-18. 23(1) : D104.
10.1051/ocl/2015062 -
Microglia in neuronal plasticity: Influence of stress
Neuropharmacology. 2015-09-01. 96 : 19-28.
10.1016/j.neuropharm.2014.12.034 -
Dietary n-3 PUFAs Deficiency Increases Vulnerability to Inflammation-Induced Spatial Memory Impairment
Neuropsychopharmacol. 2015-05-07. 40(12) : 2774-2787.
10.1038/npp.2015.127 -
Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota
Neural Plasticity. 2016-01-01. 2016 : 1-15.
10.1155/2016/3597209 -
Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
PLoS Biol. 2016-05-26. 14(5) : e1002466.
10.1371/journal.pbio.1002466 -
N-3 PUFAs and neuroinflammatory processes in cognitive disorders
OCL. 2016-01-01. 23(1) : D103.
10.1051/ocl/2015064 -
Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling.
PLoS Biol. . 14(9) : e1002554.
10.1371/journal.pbio.1002554 -
Antiinflammatory Properties of Dietary n-3 Polyunsaturated Fatty Acids Protect Against Cognitive Decline in Aging and Neurodegenerative Diseases
Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases. . : 367-384.
10.1016/b978-0-12-811959-4.00024-9 -
Roles of Microglial Phagocytosis and Inflammatory Mediators in the Pathophysiology of Sleep Disorders
Front. Cell. Neurosci.. . 11
10.3389/fncel.2017.00250 -
Role of metabolic programming in the modulation of microglia phagocytosis by lipids.
Prostaglandins, Leukotrienes and Essential Fatty Acids. . 135 : 63-73.
10.1016/j.plefa.2018.07.006 -
Isolation of Hypothalamic Microglia from Freshly Perfused Adult Mouse Brain by Magnetic-Activated Cell Sorting
JoVE. 2024-09-06. (211)
10.3791/66769 -
Rethinking the role of microglia in obesity
Neuropharmacology. 2024-04-01. : 109951.
10.1016/j.neuropharm.2024.109951 -
Discovery of a new type of neuroimmune interaction in the aged brain’s response to energy surfeit
Brain, Behavior, and Immunity. 2023-03-01.
10.1016/j.bbi.2023.03.010 -
Microglial homeostasis disruption modulates non-rapid eye movement sleep duration and neuronal activity in adult female mice
Brain, Behavior, and Immunity. 2023-01-01. 107 : 153-164.
10.1016/j.bbi.2022.09.016 -
Microglia states and nomenclature: A field at its crossroads
Neuron. 2022-11-01. 110(21) : 3458-3483.
10.1016/j.neuron.2022.10.020 -
Nanoparticles: The new promise for region-specific targeting of microglia
Matter. 2022-08-01. 5(8) : 2529-2530.
10.1016/j.matt.2022.06.048 -
Susceptibility of Female Mice to the Dietary Omega-3/Omega-6 Fatty-Acid Ratio: Effects on Adult Hippocampal Neurogenesis and Glia
Int. J. Mol. Sci.. 2022-03-21. 23(6) : 3399.
10.3390/ijms23063399 -
N-3 PUFA Deficiency Affects the Ultrastructural Organization and Density of White Matter Microglia in the Developing Brain of Male Mice.
Front. Cell. Neurosci.. 2022-02-10. 16
10.3389/fncel.2022.802411 -
Microglial Cannabinoid Type 1 Receptor Regulates Brain Inflammation in a Sex-Specific Manner
Cannabis and Cannabinoid Research. 2021-12-01. 6(6) : 488-507.
10.1089/can.2020.0170 -
Complement C3 mediates early hippocampal neurodegeneration and memory impairment in experimental multiple sclerosis
Neurobiology of Disease. 2021-12-01. 160 : 105533.
10.1016/j.nbd.2021.105533 -
N‐3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development
Glia. 2021-09-14.
10.1002/glia.24088 -
Microglia modulate hippocampal synaptic transmission and sleep duration along the light/dark cycle
Glia. 2021-09-06. 70(1) : 89-105.
10.1002/glia.24090 -
Microglia–Neuron Crosstalk in Obesity: Melodious Interaction or Kiss of Death?
IJMS. 2021-05-15. 22(10) : 5243.
10.3390/ijms22105243 -
Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain.
Nat Commun. 2020-11-30. 11(1)
10.1038/s41467-020-19861-z -
Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime
Neuropsychopharmacol.. 2020-08-11.
10.1038/s41386-020-00793-7 -
Role of Glia in the Regulation of Sleep in Health and Disease.
Comprehensive Physiology. 2020-03-12. : 687-712.
10.1002/cphy.c190022 -
Direct and indirect effects of lipids on microglia function
Neuroscience Letters. 2019-08-01. 708 : 134348.
10.1016/j.neulet.2019.134348 -
Brain eicosapentaenoic acid metabolism as a lead for novel therapeutics in major depression
Brain, Behavior, and Immunity. 2019-07-01.
10.1016/j.bbi.2019.07.001 -
Dietary N-3 PUFA deficiency affects sleep-wake activity in basal condition and in response to an inflammatory challenge in mice
Brain, Behavior, and Immunity. 2019-05-01.
10.1016/j.bbi.2019.05.016 -
Neuroinflammation and aging: Influence of dietary n-3 polyunsaturated fatty acid
OCL. 2011-11-15. 18(6)
10.1684/ocl.2011.0412 -
Dietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain
Brain, Behavior, and Immunity. 2019-02-01. 76 : 17-27.
10.1016/j.bbi.2018.07.025 -
Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation.
Brain, Behavior, and Immunity. 2018-10-01. 73 : 427-440.
10.1016/j.bbi.2018.06.004 -
Role of metabolic programming in the modulation of microglia phagocytosis by lipids.
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2018-08-01. 135 : 63-73.
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Maternal n-3 polyunsaturated fatty acid dietary supply modulates microglia lipid content in the offspring
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2018-06-01. 133 : 1-7.
10.1016/j.plefa.2018.04.003 -
Antiinflammatory Properties of Dietary n-3 Polyunsaturated Fatty Acids Protect Against Cognitive Decline in Aging and Neurodegenerative Diseases
Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases. 2018-01-01. : 367-384.
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Anti-inflammatory effects of omega-3 fatty acids in the brain: Physiological mechanisms and relevance to pharmacology
Pharmacol Rev. 2017-12-07. 70(1) : 12-38.
10.1124/pr.117.014092 -
Bioactive lipids as new class of microglial modulators: When nutrition meets neuroimunology
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2017-10-01. 79 : 19-26.
10.1016/j.pnpbp.2016.07.004 -
Roles of Microglial Phagocytosis and Inflammatory Mediators in the Pathophysiology of Sleep Disorders
Front. Cell. Neurosci.. 2017-08-30. 11
10.3389/fncel.2017.00250 -
Inhibiting Microglia Expansion Prevents Diet-Induced Hypothalamic and Peripheral Inflammation.
Diabetes. 2016-11-30. 66(4) : 908-919.
10.2337/db16-0586 -
Modulation of brain PUFA content in different experimental models of mice
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2016-11-01. 114 : 1-10.
10.1016/j.plefa.2016.09.003 -
Enriched dairy fat matrix diet prevents early life lipopolysaccharide-induced spatial memory impairment at adulthood
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2016-10-01. 113 : 9-18.
10.1016/j.plefa.2016.08.013 -
Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling.
PLoS Biol. 2016-09-20. 14(9) : e1002554.
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Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling.
PLoS Biol. 2016-09-20. 14(9) : e1002554.
10.1371/journal.pbio.1002554 -
Resolvin D1 and E1 promote resolution of inflammation in microglial cells in vitro
Brain, Behavior, and Immunity. 2016-07-01. 55 : 249-259.
10.1016/j.bbi.2015.12.013 -
N-3 polyunsaturated fatty acid and neuroinflammation in aging and Alzheimer’s disease
NUA. 2015-05-21. 3(1) : 33-47.
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Microglial Activation Enhances Associative Taste Memory through Purinergic Modulation of Glutamatergic Neurotransmission
Journal of Neuroscience. 2015-02-18. 35(7) : 3022-3033.
10.1523/jneurosci.3028-14.2015 -
Interleukin-6 activates arginine vasopressin neurons in the supraoptic nucleus during immune challenge in rats
American Journal of Physiology-Endocrinology and Metabolism. 2009-06-01. 296(6) : E1289-E1299.
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Shaping of motor responses by incentive values through the basal ganglia.
Journal of Neuroscience. 2007-01-31. 27(5) : 1176-1183.
10.1523/jneurosci.3745-06.2007 -
Phenotype of striatofugal medium spiny neurons in parkinsonian and dyskinetic nonhuman primates: a call for a reappraisal of the functional organization of the basal ganglia.
Journal of Neuroscience. 2006-08-23. 26(34) : 8653-8661.
10.1523/jneurosci.2582-06.2006 -
Inactivation of the Cerebral NFκB Pathway Inhibits Interleukin-1β-Induced Sickness Behavior and c-Fos Expression in Various Brain Nuclei
Neuropsychopharmacol. 2005-05-18. 30(8) : 1492-1499.
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Signaling pathways of interleukin-1 actions in the brain: anatomical distribution of phospho-ERK1/2 in the brain of rat treated systemically with interleukin-1beta.
Neuroscience. 2005-01-01. 134(3)
10.1016/j.neuroscience.2005.04.035 1104537600 -
NFκB Activates in vivo the Synthesis of Inducible Cox-2 in the Brain
J Cereb Blood Flow Metab. 2005-03-09. 25(8) : 1047-1059.
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Book review: Interleukin protocols, methods in molecular medicine, vol. 70
Psychoneuroendocrinology. 2003-04-01. 28(3) : 475-476.
10.1016/s0306-4530(02)00071-9