Agnès Nadjar
Responsable d'équipe / Professeure
Professeure / Université de Bordeaux/ Équipe
Neuroimmunologie des pathologies et de la santé métabolique (NOMAD) (Nadjar )
Institut des Maladies Neurodégénératives
/ Contact
www.orcid.org/0000-0002-3969-6530
Je m’intéresse depuis toujours aux interactions neuroimmunes et à leur modulation par l’environnement. Aujourd’hui, mon équipe étudie comment les cellules immunitaires du cerveau — microglies et immunité méningée — régulent le métabolisme énergétique, dans l’objectif de tirer parti de ces mécanismes pour prévenir ou ralentir des maladies neurodégénératives comme Alzheimer, qui s’accompagnent de profondes perturbations métaboliques.
Axes de recherche
Axe principal
Axe secondaire
Publications
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Isolation of Hypothalamic Microglia from Freshly Perfused Adult Mouse Brain by Magnetic-Activated Cell Sorting
JoVE. 2024-09-06. (211)
10.3791/66769 -
Rethinking the role of microglia in obesity
Neuropharmacology. 2024-04-01. : 109951.
10.1016/j.neuropharm.2024.109951 -
Discovery of a new type of neuroimmune interaction in the aged brain’s response to energy surfeit
Brain, Behavior, and Immunity. 2023-03-01.
10.1016/j.bbi.2023.03.010 -
Microglial homeostasis disruption modulates non-rapid eye movement sleep duration and neuronal activity in adult female mice
Brain, Behavior, and Immunity. 2023-01-01. 107 : 153-164.
10.1016/j.bbi.2022.09.016 -
Microglia states and nomenclature: A field at its crossroads
Neuron. 2022-11-01. 110(21) : 3458-3483.
10.1016/j.neuron.2022.10.020 -
Nanoparticles: The new promise for region-specific targeting of microglia
Matter. 2022-08-01. 5(8) : 2529-2530.
10.1016/j.matt.2022.06.048 -
Susceptibility of Female Mice to the Dietary Omega-3/Omega-6 Fatty-Acid Ratio: Effects on Adult Hippocampal Neurogenesis and Glia
Int. J. Mol. Sci.. 2022-03-21. 23(6) : 3399.
10.3390/ijms23063399 -
N-3 PUFA Deficiency Affects the Ultrastructural Organization and Density of White Matter Microglia in the Developing Brain of Male Mice.
Front. Cell. Neurosci.. 2022-02-10. 16
10.3389/fncel.2022.802411 -
Microglial Cannabinoid Type 1 Receptor Regulates Brain Inflammation in a Sex-Specific Manner
Cannabis and Cannabinoid Research. 2021-12-01. 6(6) : 488-507.
10.1089/can.2020.0170 -
Complement C3 mediates early hippocampal neurodegeneration and memory impairment in experimental multiple sclerosis
Neurobiology of Disease. 2021-12-01. 160 : 105533.
10.1016/j.nbd.2021.105533 -
N‐3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development
Glia. 2021-09-14.
10.1002/glia.24088 -
Microglia modulate hippocampal synaptic transmission and sleep duration along the light/dark cycle
Glia. 2021-09-06. 70(1) : 89-105.
10.1002/glia.24090 -
Microglia–Neuron Crosstalk in Obesity: Melodious Interaction or Kiss of Death?
IJMS. 2021-05-15. 22(10) : 5243.
10.3390/ijms22105243 -
Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain.
Nat Commun. 2020-11-30. 11(1)
10.1038/s41467-020-19861-z -
Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime
Neuropsychopharmacol.. 2020-08-11.
10.1038/s41386-020-00793-7 -
Role of Glia in the Regulation of Sleep in Health and Disease.
Comprehensive Physiology. 2020-03-12. : 687-712.
10.1002/cphy.c190022 -
Direct and indirect effects of lipids on microglia function
Neuroscience Letters. 2019-08-01. 708 : 134348.
10.1016/j.neulet.2019.134348 -
Brain eicosapentaenoic acid metabolism as a lead for novel therapeutics in major depression
Brain, Behavior, and Immunity. 2019-07-01.
10.1016/j.bbi.2019.07.001 -
Dietary N-3 PUFA deficiency affects sleep-wake activity in basal condition and in response to an inflammatory challenge in mice
Brain, Behavior, and Immunity. 2019-05-01.
10.1016/j.bbi.2019.05.016 -
Neuroinflammation and aging: Influence of dietary n-3 polyunsaturated fatty acid
OCL. 2011-11-15. 18(6)
10.1684/ocl.2011.0412 -
Dietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain
Brain, Behavior, and Immunity. 2019-02-01. 76 : 17-27.
10.1016/j.bbi.2018.07.025 -
Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation.
Brain, Behavior, and Immunity. 2018-10-01. 73 : 427-440.
10.1016/j.bbi.2018.06.004 -
Role of metabolic programming in the modulation of microglia phagocytosis by lipids.
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2018-08-01. 135 : 63-73.
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Maternal n-3 polyunsaturated fatty acid dietary supply modulates microglia lipid content in the offspring
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2018-06-01. 133 : 1-7.
10.1016/j.plefa.2018.04.003 -
Antiinflammatory Properties of Dietary n-3 Polyunsaturated Fatty Acids Protect Against Cognitive Decline in Aging and Neurodegenerative Diseases
Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases. 2018-01-01. : 367-384.
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Anti-inflammatory effects of omega-3 fatty acids in the brain: Physiological mechanisms and relevance to pharmacology
Pharmacol Rev. 2017-12-07. 70(1) : 12-38.
10.1124/pr.117.014092 -
Bioactive lipids as new class of microglial modulators: When nutrition meets neuroimunology
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2017-10-01. 79 : 19-26.
10.1016/j.pnpbp.2016.07.004 -
Roles of Microglial Phagocytosis and Inflammatory Mediators in the Pathophysiology of Sleep Disorders
Front. Cell. Neurosci.. 2017-08-30. 11
10.3389/fncel.2017.00250 -
Inhibiting Microglia Expansion Prevents Diet-Induced Hypothalamic and Peripheral Inflammation.
Diabetes. 2016-11-30. 66(4) : 908-919.
10.2337/db16-0586 -
Modulation of brain PUFA content in different experimental models of mice
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2016-11-01. 114 : 1-10.
10.1016/j.plefa.2016.09.003 -
Enriched dairy fat matrix diet prevents early life lipopolysaccharide-induced spatial memory impairment at adulthood
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2016-10-01. 113 : 9-18.
10.1016/j.plefa.2016.08.013 -
Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling.
PLoS Biol. 2016-09-20. 14(9) : e1002554.
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Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling.
PLoS Biol. 2016-09-20. 14(9) : e1002554.
10.1371/journal.pbio.1002554 -
Resolvin D1 and E1 promote resolution of inflammation in microglial cells in vitro
Brain, Behavior, and Immunity. 2016-07-01. 55 : 249-259.
10.1016/j.bbi.2015.12.013 -
N-3 polyunsaturated fatty acid and neuroinflammation in aging and Alzheimer’s disease
NUA. 2015-05-21. 3(1) : 33-47.
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Microglial Activation Enhances Associative Taste Memory through Purinergic Modulation of Glutamatergic Neurotransmission
Journal of Neuroscience. 2015-02-18. 35(7) : 3022-3033.
10.1523/jneurosci.3028-14.2015 -
Interleukin-6 activates arginine vasopressin neurons in the supraoptic nucleus during immune challenge in rats
American Journal of Physiology-Endocrinology and Metabolism. 2009-06-01. 296(6) : E1289-E1299.
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Shaping of motor responses by incentive values through the basal ganglia.
Journal of Neuroscience. 2007-01-31. 27(5) : 1176-1183.
10.1523/jneurosci.3745-06.2007 -
Phenotype of striatofugal medium spiny neurons in parkinsonian and dyskinetic nonhuman primates: a call for a reappraisal of the functional organization of the basal ganglia.
Journal of Neuroscience. 2006-08-23. 26(34) : 8653-8661.
10.1523/jneurosci.2582-06.2006 -
Inactivation of the Cerebral NFκB Pathway Inhibits Interleukin-1β-Induced Sickness Behavior and c-Fos Expression in Various Brain Nuclei
Neuropsychopharmacol. 2005-05-18. 30(8) : 1492-1499.
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Signaling pathways of interleukin-1 actions in the brain: anatomical distribution of phospho-ERK1/2 in the brain of rat treated systemically with interleukin-1beta.
Neuroscience. 2005-01-01. 134(3)
10.1016/j.neuroscience.2005.04.035 1104537600 -
NFκB Activates in vivo the Synthesis of Inducible Cox-2 in the Brain
J Cereb Blood Flow Metab. 2005-03-09. 25(8) : 1047-1059.
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Book review: Interleukin protocols, methods in molecular medicine, vol. 70
Psychoneuroendocrinology. 2003-04-01. 28(3) : 475-476.
10.1016/s0306-4530(02)00071-9