Venue: Centre Broca
Equipe Marsicano, Neurocentre Magendie.
Supervisors : Giovanni Marsicano and Jaideep Bains.
Title
The role of astrocytes in social transmission of stress
Abstract
In threating situations, stress mechanisms override most other functions, including cognitive abilities not directly related to the danger itself. Stress-associated information can be transmitted from stressed to naïve individuals through olfactory signals, but the impact of this socially-transmitted stress on higher order cognitive processes is currently unknown. The olfactory bulb, the first relay of olfactory information in the main nervous system, controls information processing related to specific odors and sends information to other brain regions to translate sensory odor inputs into complex behaviors. The present thesis explores the role of astrocytes, and particularly of mitochondrial cannabinoid-type 1 receptors in these cells, in the olfactory transmission of stress information and the cognitive consequences this has in mice, using a combination of in vivo approaches in mice.