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Séminaire Yasunori Hayashi

13 juillet 2018 / 11:30

The mechanism converting a transient Ca2+-signaling into persistent biochemical signaling during LTP., The mechanism converting a transient Ca2+-signaling into persistent biochemical signaling during LTP.

Abstract :

Long-term synaptic plasticity requires a mechanism that converts short Ca2+ pulses into persistent biochemical signaling to support the changes in the function and structure of synapses over long period of time. Here, we present a positive feedback loop, formed by a « reciprocally activating kinase-effector complex » (RAKEC) in dendritic spines, enabling the persistence and confinement of the molecular memory. We found that stimulation of a single spine causes the rapid formation of a RAKEC consists of a kinase CaMKII and its substrate a RacGEF TIAM1, which can stably promote actin-polymerization through Rac1, thereby maintaining the structure of the spine over a long period of time during LTP. This is achieved by a pseudo-autoinhibitory domain found within TIAM1, homologous to the autoinhibitory domain of CaMKII. RAKEC can store biochemical information in small subcellular compartments, thus potentially serving as a general mechanism for the production of prolonged and compartmentalized signaling.

Prochainement

  1. Séminaire – Suzana Herculano-Houzel

    vendredi 26 avril 2019 / 11:30

    Invitant : Thomas Boraud

  2. Séminaire impromptu – Maxime Assous

    vendredi 3 mai 2019 / 10:00 - 11:30

    Extrinsic innervation of striatal interneurons and implications for the local microcircuitry.

  3. Conférence mensuelle – Richard Robitaille

    vendredi 3 mai 2019 / 11:30 - 12:30

    Regulation of synaptic structure ad function by glial celles in health and disease

  4. Séminaire – Stéphanie Trouche

    vendredi 10 mai 2019 / 11:30 - 12:30

    Invitant : Catherine Le Moine

  5. Journée Bordeaux Neurocampus

    mercredi 15 mai 2019 / 09:00 - 18:00

    (Haut Carré, Talence)

Détails

Date :
13 juillet 2018
Heure :
11:30
Catégorie d’Évènement: